Feasibility of a semi-automated method for cardiac conduction velocity analysis of high-resolution activation maps

Ashish N. Doshi, Richard D. Walton, Sébastien P. Krul, Joris R. de Groot, Olivier Bernus, Igor R. Efimov, Bastiaan J. Boukens*, Ruben Coronel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Myocardial conduction velocity is important for the genesis of arrhythmias. In the normal heart, conduction is primarily dependent on fiber direction (anisotropy) and may be discontinuous at sites with tissue heterogeneities (trabeculated or fibrotic tissue). We present a semi-automated method for the accurate measurement of conduction velocity based on high-resolution activation mapping following central stimulation. The method was applied to activation maps created from myocardium from man, sheep and mouse with anisotropic and discontinuous conduction. Advantages of the presented method over existing methods are discussed.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalComputers in Biology and Medicine
Volume65
DOIs
StatePublished - Oct 1 2015

Keywords

  • Arrhythmia
  • Conduction velocity
  • Electrophysiology
  • Fibrosis
  • Optical mapping

ASJC Scopus subject areas

  • Health Informatics
  • Computer Science Applications

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