Feasibility of detecting mineral content in turbid medium using stimulated Raman photoacoustic imaging

Rajan Arora; Georgi I. Petrov; Hao F Zhang; Vladislav V. Yakovlev

doi:10.1117/12.875442

Feasibility of detecting mineral content in turbid medium using stimulated Raman photoacoustic imaging

Rajan Arora, Georgi I. Petrov, Hao F Zhang, Vladislav V. Yakovlev

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Osteoporosis is a bone disease that leads to the increasing risk of bone fracture. It is associated with a reduced mineral content, which results in the change of the bone architecture. Raman spectroscopy has an intrinsic sensitivity to the chemical content of the bone, but its application to study bones in vivo is limited due to strong optical scattering in tissue. It is proposed that Raman excitation with photoacoustic detection can successfully address the problem of chemically specific imaging in deep tissue. In this report, the principal possibility of such approach is evaluated.

Original language	English (US)
Title of host publication	Multimodal Biomedical Imaging VI
Volume	7892
DOIs	https://doi.org/10.1117/12.875442
State	Published - May 2 2011
Event	Multimodal Biomedical Imaging VI - San Francisco, CA, United States Duration: Jan 22 2011 → Jan 23 2011

Other

Other	Multimodal Biomedical Imaging VI
Country	United States
City	San Francisco, CA
Period	1/22/11 → 1/23/11

Keywords

nonlinear Raman imaging
osteoporosis
photoacoustics
stimulated Raman scattering

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

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title = "Feasibility of detecting mineral content in turbid medium using stimulated Raman photoacoustic imaging",

abstract = "Osteoporosis is a bone disease that leads to the increasing risk of bone fracture. It is associated with a reduced mineral content, which results in the change of the bone architecture. Raman spectroscopy has an intrinsic sensitivity to the chemical content of the bone, but its application to study bones in vivo is limited due to strong optical scattering in tissue. It is proposed that Raman excitation with photoacoustic detection can successfully address the problem of chemically specific imaging in deep tissue. In this report, the principal possibility of such approach is evaluated.",

keywords = "nonlinear Raman imaging, osteoporosis, photoacoustics, stimulated Raman scattering",

author = "Rajan Arora and Petrov, {Georgi I.} and Zhang, {Hao F} and Yakovlev, {Vladislav V.}",

year = "2011",

month = may,

day = "2",

doi = "10.1117/12.875442",

language = "English (US)",

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booktitle = "Multimodal Biomedical Imaging VI",

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T1 - Feasibility of detecting mineral content in turbid medium using stimulated Raman photoacoustic imaging

AU - Arora, Rajan

AU - Petrov, Georgi I.

AU - Zhang, Hao F

AU - Yakovlev, Vladislav V.

PY - 2011/5/2

Y1 - 2011/5/2

N2 - Osteoporosis is a bone disease that leads to the increasing risk of bone fracture. It is associated with a reduced mineral content, which results in the change of the bone architecture. Raman spectroscopy has an intrinsic sensitivity to the chemical content of the bone, but its application to study bones in vivo is limited due to strong optical scattering in tissue. It is proposed that Raman excitation with photoacoustic detection can successfully address the problem of chemically specific imaging in deep tissue. In this report, the principal possibility of such approach is evaluated.

AB - Osteoporosis is a bone disease that leads to the increasing risk of bone fracture. It is associated with a reduced mineral content, which results in the change of the bone architecture. Raman spectroscopy has an intrinsic sensitivity to the chemical content of the bone, but its application to study bones in vivo is limited due to strong optical scattering in tissue. It is proposed that Raman excitation with photoacoustic detection can successfully address the problem of chemically specific imaging in deep tissue. In this report, the principal possibility of such approach is evaluated.

KW - nonlinear Raman imaging

KW - osteoporosis

KW - photoacoustics

KW - stimulated Raman scattering

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U2 - 10.1117/12.875442

DO - 10.1117/12.875442

M3 - Conference contribution

AN - SCOPUS:79955374946

SN - 9780819484291

VL - 7892

BT - Multimodal Biomedical Imaging VI

T2 - Multimodal Biomedical Imaging VI

Y2 - 22 January 2011 through 23 January 2011

ER -

Feasibility of detecting mineral content in turbid medium using stimulated Raman photoacoustic imaging

Abstract

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Keywords

ASJC Scopus subject areas

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