Feasibility of detecting mineral content in turbid medium using stimulated Raman photoacoustic imaging

Rajan Arora, Georgi I. Petrov, Hao F Zhang, Vladislav V. Yakovlev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Osteoporosis is a bone disease that leads to the increasing risk of bone fracture. It is associated with a reduced mineral content, which results in the change of the bone architecture. Raman spectroscopy has an intrinsic sensitivity to the chemical content of the bone, but its application to study bones in vivo is limited due to strong optical scattering in tissue. It is proposed that Raman excitation with photoacoustic detection can successfully address the problem of chemically specific imaging in deep tissue. In this report, the principal possibility of such approach is evaluated.

Original languageEnglish (US)
Title of host publicationMultimodal Biomedical Imaging VI
Volume7892
DOIs
StatePublished - May 2 2011
EventMultimodal Biomedical Imaging VI - San Francisco, CA, United States
Duration: Jan 22 2011Jan 23 2011

Other

OtherMultimodal Biomedical Imaging VI
CountryUnited States
CitySan Francisco, CA
Period1/22/111/23/11

Keywords

  • nonlinear Raman imaging
  • osteoporosis
  • photoacoustics
  • stimulated Raman scattering

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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