Feasibility study of tumor size estimation through time domain peak monitoring

Mark C. Converse; Muwu Hou; David M. Mahvi; John G. Webster

doi:10.1109/TBME.2007.899308

Feasibility study of tumor size estimation through time domain peak monitoring

Mark C. Converse^*, Muwu Hou, David M. Mahvi, John G. Webster

^*Corresponding author for this work

Surgery, Surgical Oncology Division

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A new ultrawideband (UWB) microwave method to estimate tumor size based upon detection of the tumor/liver interface is proposed. This method involves monitoring the response of a broadband pulse launched down a coaxial treatment antenna and radiated into the tumor. By monitoring the peak in the returned signal, and estimating the propagation velocity within the tumor, the location of the tumor/liver interface can be determined and the size of a spherical lesion estimated. The feasibility of this technique is demonstrated by finite element (FE) electromagnetic simulations of a spherical tumor in the liver. Robustness to noise is also investigated as well as the effects of insertion depth. The promising outcome of this feasibility study suggests that further development of this technique should be pursued.

Original language	English (US)
Pages (from-to)	230-236
Number of pages	7
Journal	IEEE Transactions on Biomedical Engineering
Volume	55
Issue number	1
DOIs	https://doi.org/10.1109/TBME.2007.899308
State	Published - Jan 2008

Keywords

Electromagnetic simulation
Finite element method (FEM)
Microwave
Time domain
Tumor

ASJC Scopus subject areas

Biomedical Engineering

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10.1109/TBME.2007.899308

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abstract = "A new ultrawideband (UWB) microwave method to estimate tumor size based upon detection of the tumor/liver interface is proposed. This method involves monitoring the response of a broadband pulse launched down a coaxial treatment antenna and radiated into the tumor. By monitoring the peak in the returned signal, and estimating the propagation velocity within the tumor, the location of the tumor/liver interface can be determined and the size of a spherical lesion estimated. The feasibility of this technique is demonstrated by finite element (FE) electromagnetic simulations of a spherical tumor in the liver. Robustness to noise is also investigated as well as the effects of insertion depth. The promising outcome of this feasibility study suggests that further development of this technique should be pursued.",

keywords = "Electromagnetic simulation, Finite element method (FEM), Microwave, Time domain, Tumor",

author = "Converse, {Mark C.} and Muwu Hou and Mahvi, {David M.} and Webster, {John G.}",

note = "Funding Information: Manuscript received December 26, 2006. This work was supported by the National Institute of Health (NIH) under Grant DK58839. Asterisk indicates corresponding author. *M. C. Converse is with the Department of Surgery, University of Wisconsin, 2151 Engineering Centers Building, 1550 Engineering Drive, Madison, WI 53706 USA (e-mail: converse@cae.wisc.edu). M. Hou is with the Department of Electrical and Computer Engineering, University of Wisconsin, Madison, WI 53706 USA. D. M. Mahvi is with the Department of Surgery, University of Wisconsin, Madison, WI 53792 USA. J. G. Webster is with the Department of Biomedical Engineering, University of Wisconsin, Madison, WI 53706 USA. Digital Object Identifier 10.1109/TBME.2007.899308",

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Feasibility study of tumor size estimation through time domain peak monitoring

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