Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection and Other Conditions in Children: A Joint Position Paper from the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition

Zev H. Davidovics, Sonia Michail, Maribeth R. Nicholson, Larry K. Kociolek, Nikhil Pai, Richard Hansen, Tobias Schwerd, Aldo Maspons, Raanan Shamir, Hania Szajewska, Nikhil Thapar, Tim De Meij, Alexis Mosca, Yvan Vandenplas, Stacy A. Kahn, Richard Kellermayer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Fecal microbiota transplantation (FMT) is becoming part of the treatment algorithms against recurrent Clostridium difficile infection (rCDI) both in adult and pediatric gastroenterology practice. With our increasing recognition of the critical role the microbiome plays in human health and disease, FMT is also being considered as a potential therapy for other disorders, including inflammatory bowel disease (Crohn disease, ulcerative colitis), graft versus host disease, neuropsychiatric diseases, and metabolic syndrome. Controlled trials with FMT for rCDI have not been performed in children, and numerous clinical and regulatory considerations have to be considered when using this untraditional therapy. This report is intended to provide guidance for FMT in the treatment of rCDI in pediatric patients.

Original languageEnglish (US)
Pages (from-to)130-143
Number of pages14
JournalJournal of pediatric gastroenterology and nutrition
Volume68
Issue number1
DOIs
StatePublished - 2019

Keywords

  • Clostridium difficile
  • child
  • fecal
  • fecal transplantation
  • microbiome
  • microbiota
  • pediatric

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

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