Feldkamp and circle-and-line cone-beam reconstruction for 3D micro-CT of vascular networks

Roger H. Johnson*, Hui Hu, Steven T. Haworth, Paul S. Cho, Christopher A. Dawson, John H. Linehan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Detailed morphometric knowledge of the microvascular network is needed for studies relating structure to haemodynamic function in organs like the lung. Clinical volumetric CT is limited to millimetre-order spatial resolution. Since evidence suggests that small arterioles (50 to 300 micrometres) dominate pulmonary haemodynamics, we built a micro-CT scanner, capable of imaging excised lungs in 3D with 100/μm resolution, for basic physiology research. The scanner incorporates a micro-focal (3 μm) x-ray source, an xyzθ stage and a CCD-coupled image intensifier detector. We imaged phantoms and contrast-enhanced rat lungs, reconstructing the data with either the Feldkamp or the circle-and-line cone-beam reconstruction algorithm. We present reconstructions using 180 views over 360 degrees for the circular trajectory, augmented with views from a linear scan for the circle-and-line algorithm, Especially for platelike features perpendicular to the rotation axis and remote from the midplane, the circle-and-line algorithm produces superior reconstructions compared with Feldkamp's algorithm. We conclude that the use of nonplanar source trajectories to perform micro-CT on contrast-enhanced, excised lungs can provide data useful for morphometric analysis of vascular trees, currently down to the 130 μm level.

Original languageEnglish (US)
Pages (from-to)929-940
Number of pages12
JournalPhysics in Medicine and Biology
Volume43
Issue number4
DOIs
StatePublished - Apr 1998

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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