Female reproductive health after childhood, adolescent, and young adult cancers: Guidelines for the assessment and management of female reproductive complications

Monika L. Metzger*, Lillian R. Meacham, Briana Patterson, Jacqueline S. Casillas, Louis S. Constine, Nobuko Hijiya, Lisa B. Kenney, Marcia Leonard, Barbara A. Lockart, Wendy Likes, Daniel M. Green

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

101 Scopus citations

Abstract

Purpose: As more young female patients with cancer survive their primary disease, concerns about reproductive health related to primary therapy gain relevance. Cancer therapy can often affect reproductive organs, leading to impaired pubertal development, hormonal regulation, fertility, and sexual function, affecting quality of life. Methods: The Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancer (COG-LTFU Guidelines) are evidence-based recommendations for screening and management of late effects of therapeutic exposures. The guidelines are updated every 2 years by a multidisciplinary panel based on current literature review and expert consensus. Results: This review summarizes the current task force recommendations for the assessment and management of female reproductive complications after treatment for childhood, adolescent, and young adult cancers. Experimental pretreatment as well as post-treatment fertility preservation strategies, including barriers and ethical considerations, which are not included in the COG-LTFU Guidelines, are also discussed. Conclusion: Ongoing research will continue to inform COG-LTFU Guideline recommendations for follow-up care of female survivors of childhood cancer to improve their health and quality of life.

Original languageEnglish (US)
Pages (from-to)1239-1247
Number of pages9
JournalJournal of Clinical Oncology
Volume31
Issue number9
DOIs
StatePublished - Mar 20 2013

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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