Fentanyl HCl iontophoretic transdermal system versus intravenous morphine pump after gynecologic surgery

Shireen Ahmad*, David J. Hewitt, C. V. Damaraju

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Objective: To compare the efficacy and safety of fentanyl iontophoretic transdermal system (ITS) with morphine intravenous patient-controlled analgesia (IV PCA) for pain management following gynecologic surgery. Method: A subgroup (n = 275) of gynecologic surgery patients from a randomized study (N = 636) of patients treated with fentanyl ITS or morphine IV PCA was analyzed. The main efficacy endpoint was the patient global assessment (PGA) of the method of pain control (first 24 h). Result: In gynecologic surgery patients, PGA success ratings (excellent/good) were statistically equivalent (fentanyl ITS, 84.8%; morphine IV PCA, 83.9%; 95% confidence interval: -7.7%, 9.4%) based on the prespecified equivalence criterion of 10% for the entire study population. Pain intensity at 3 h (P = 0.296), discontinuations due to inadequate analgesia (P = 0.148), and percentages of patients requesting supplemental opioids in the first 3 h (P = 0.524) were similar. Conclusion: The two modalities were therapeutically equivalent for pain management in these gynecologic surgery patients.

Original languageEnglish (US)
Pages (from-to)251-258
Number of pages8
JournalArchives of Gynecology and Obstetrics
Volume276
Issue number3
DOIs
StatePublished - Sep 1 2007

Keywords

  • Fentanyl
  • Gynecologic surgery
  • Pain
  • Patient-controlled analgesia
  • Postoperative analgesia

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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