Fertility Preservation in a Female Adolescent with a Hemoglobinopathy

Mary Ellen Pavone; Sharrón Manuel; Alexis A Thompson

doi:10.1007/978-3-030-02868-8_61

Fertility Preservation in a Female Adolescent with a Hemoglobinopathy

Mary Ellen Pavone^*, Sharrón Manuel, Alexis A Thompson

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

A 16-year-old female with a history of β-thalassemia presented to our Reproductive Endocrinology and Infertility (REI) clinic prior to undergoing hematopoietic stem cell transplantation (HSCT). Her gynecologic history was significant for spontaneous menarche at age 13 years and regular monthly menses. She was not sexually active but did use tampons. Her history was otherwise significant for mild asthma and a history of depression for which she saw a therapist but was not prescribed medications. She was able to tolerate a transvaginal ultrasound, which revealed a normal-sized uterus and an antral follicle count of 12. Laboratory results were notable for an anti-Müllerian hormone (AMH) level of 3.41 ng/mL. She was counseled that the preconditioning regimens used prior to HSCT could lead to premature ovarian insufficiency and therefore she should consider fertility preservation. She was counseled about preservation options and elected to undergo oocyte cryopreservation.

Original language	English (US)
Title of host publication	Textbook of Oncofertility Research and Practice
Subtitle of host publication	A Multidisciplinary Approach
Publisher	Springer International Publishing
Pages	551-557
Number of pages	7
ISBN (Electronic)	9783030028688
ISBN (Print)	9783030028671
DOIs	https://doi.org/10.1007/978-3-030-02868-8_61
State	Published - Jan 1 2019

Keywords

Female adolescent
Fertility preservation
Hemoglobinopathy
Oocyte cryopreservation

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-3-030-02868-8_61

Cite this

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title = "Fertility Preservation in a Female Adolescent with a Hemoglobinopathy",

abstract = "A 16-year-old female with a history of β-thalassemia presented to our Reproductive Endocrinology and Infertility (REI) clinic prior to undergoing hematopoietic stem cell transplantation (HSCT). Her gynecologic history was significant for spontaneous menarche at age 13 years and regular monthly menses. She was not sexually active but did use tampons. Her history was otherwise significant for mild asthma and a history of depression for which she saw a therapist but was not prescribed medications. She was able to tolerate a transvaginal ultrasound, which revealed a normal-sized uterus and an antral follicle count of 12. Laboratory results were notable for an anti-M{\"u}llerian hormone (AMH) level of 3.41 ng/mL. She was counseled that the preconditioning regimens used prior to HSCT could lead to premature ovarian insufficiency and therefore she should consider fertility preservation. She was counseled about preservation options and elected to undergo oocyte cryopreservation.",

keywords = "Female adolescent, Fertility preservation, Hemoglobinopathy, Oocyte cryopreservation",

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AU - Manuel, Sharrón

AU - Thompson, Alexis A

N1 - Publisher Copyright: © Springer Nature Switzerland AG 2019.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - A 16-year-old female with a history of β-thalassemia presented to our Reproductive Endocrinology and Infertility (REI) clinic prior to undergoing hematopoietic stem cell transplantation (HSCT). Her gynecologic history was significant for spontaneous menarche at age 13 years and regular monthly menses. She was not sexually active but did use tampons. Her history was otherwise significant for mild asthma and a history of depression for which she saw a therapist but was not prescribed medications. She was able to tolerate a transvaginal ultrasound, which revealed a normal-sized uterus and an antral follicle count of 12. Laboratory results were notable for an anti-Müllerian hormone (AMH) level of 3.41 ng/mL. She was counseled that the preconditioning regimens used prior to HSCT could lead to premature ovarian insufficiency and therefore she should consider fertility preservation. She was counseled about preservation options and elected to undergo oocyte cryopreservation.

AB - A 16-year-old female with a history of β-thalassemia presented to our Reproductive Endocrinology and Infertility (REI) clinic prior to undergoing hematopoietic stem cell transplantation (HSCT). Her gynecologic history was significant for spontaneous menarche at age 13 years and regular monthly menses. She was not sexually active but did use tampons. Her history was otherwise significant for mild asthma and a history of depression for which she saw a therapist but was not prescribed medications. She was able to tolerate a transvaginal ultrasound, which revealed a normal-sized uterus and an antral follicle count of 12. Laboratory results were notable for an anti-Müllerian hormone (AMH) level of 3.41 ng/mL. She was counseled that the preconditioning regimens used prior to HSCT could lead to premature ovarian insufficiency and therefore she should consider fertility preservation. She was counseled about preservation options and elected to undergo oocyte cryopreservation.

KW - Female adolescent

KW - Fertility preservation

KW - Hemoglobinopathy

KW - Oocyte cryopreservation

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DO - 10.1007/978-3-030-02868-8_61

M3 - Chapter

AN - SCOPUS:105011021918

SN - 9783030028671

SP - 551

EP - 557

BT - Textbook of Oncofertility Research and Practice

PB - Springer International Publishing

ER -

Fertility Preservation in a Female Adolescent with a Hemoglobinopathy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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