Fetal diagnosis of KCNQ1-variant long QT syndrome using fetal echocardiography and magnetocardiography

Lajja Desai; Ron Wakai; Sabrina Tsao; Janette Strasburger; Nina Gotteiner; Angira Patel

doi:10.1111/pace.13900

Fetal diagnosis of KCNQ1-variant long QT syndrome using fetal echocardiography and magnetocardiography

Lajja Desai^*, Ron Wakai, Sabrina Tsao, Janette Strasburger, Nina Gotteiner, Angira Patel

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A pregnant woman with KCNQ1 variant long QT syndrome (LQTS) underwent fetal magnetocardiography (fMCG) after atrioventricular (AV) block was noted during fetal echocardiogram—atypical for LQTS type 1. Concern for fetal LQTS on fMCG prompted monitoring of maternal labs, change of maternal beta blocker therapy, and frequent fetal echocardiograms. Collaboration between obstetricians, neonatologists, and pediatric cardiologists ensured safe delivery. Beta blocker therapy was initiated after birth, and postnatal evaluation confirmed genotype and phenotype positive LQTS in the infant. Our experience suggests diagnosis and evaluation of fetal LQTS can alter antenatal management to reduce risk of poor fetal and postnatal outcomes.

Original language	English (US)
Pages (from-to)	430-433
Number of pages	4
Journal	PACE - Pacing and Clinical Electrophysiology
Volume	43
Issue number	4
DOIs	https://doi.org/10.1111/pace.13900
State	Published - Apr 1 2020

Keywords

fetal bradycardia
fetal echocardiography
fetal magnetocardiography
long QT syndrome

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1111/pace.13900

Cite this

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abstract = "A pregnant woman with KCNQ1 variant long QT syndrome (LQTS) underwent fetal magnetocardiography (fMCG) after atrioventricular (AV) block was noted during fetal echocardiogram—atypical for LQTS type 1. Concern for fetal LQTS on fMCG prompted monitoring of maternal labs, change of maternal beta blocker therapy, and frequent fetal echocardiograms. Collaboration between obstetricians, neonatologists, and pediatric cardiologists ensured safe delivery. Beta blocker therapy was initiated after birth, and postnatal evaluation confirmed genotype and phenotype positive LQTS in the infant. Our experience suggests diagnosis and evaluation of fetal LQTS can alter antenatal management to reduce risk of poor fetal and postnatal outcomes.",

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AU - Strasburger, Janette

AU - Gotteiner, Nina

AU - Patel, Angira

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KW - fetal magnetocardiography

KW - long QT syndrome

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Fetal diagnosis of KCNQ1-variant long QT syndrome using fetal echocardiography and magnetocardiography

Abstract

Keywords

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