Fetal fibronectin levels are elevated in maternal plasma and amniotic fluid of patients with severe preeclampsia

Michael J. Kupfermine*, Alan M Peaceman, Thomas R. Wigton, Karen A. Rehnberg, Michael L Socol

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

OBJECTIVE: Our purpose was to investigate levels of fetal fibronectin in maternal plasma, amniotic fluid, and umbilical cord plasma from patients with severe preeclampsia. STUDY DESIGN: The study group comprised 20 patients with severe preeclampsia (group A). An antopartum comparison group was composed of 20 healthy patients matched for gestational age (group B). An intrapartum control group consisted of 20 term normotensive patients (group C). Maternal plasma samples were collected before labor (groups A and B), then immediately after delivery, and again at 20 to 24 hours post partum (groups A and C). Amniotic fluid was also collected in early labor, and umbilical cord blood was collected at delivery (groups A and C). Samples were assayed for fetal fibronectin by a specific enzyme-linked immunoassay. RESULTS: Before labor maternal plasma levels of fetal fibronectin were significantly elevated in preeclamptic patients compared with patients in group B (p < 0.0001). Plasma levels of fetal fibronectin were also increased in preeclamptic patients compared with patients in group C at delivery (p < 0.0001) and post partum (p < 0.05). Additionally, amniotic fluid levels of fetal fibronectin in the preeclamptic patients were significantly increased (p < 0.05). In contrast, umbilical cord plasma fetal fibronectin concentrations from the preeclamptic and control patients were similar. CONCLUSIONS: Fetal fibronectin is elevated in the maternal plasma and amniotic fluid, but not umbilical cord plasma, of patients with severe preeclampsia. These findings suggest an increase in production of fetal fibronectin from chorionic trophoblasts in patients with preeclampsia or an abnormal interaction between chorionic trophoblast and decidua with reusltant increased leakage into the maternal circulation and amniotic fluid.

Original languageEnglish (US)
Pages (from-to)649-653
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume172
Issue number2 PART 1
DOIs
StatePublished - Jan 1 1995

Fingerprint

Amniotic Fluid
Pre-Eclampsia
Fibronectins
Mothers
Umbilical Cord
Trophoblasts
Decidua
Immunoenzyme Techniques
Fetal Blood
Gestational Age
Age Groups

Keywords

  • Preeclampsia
  • amniotic fluid
  • fetal fibronectin
  • plasma

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

@article{e5eea05180c144fd9da9a76a2685ab29,
title = "Fetal fibronectin levels are elevated in maternal plasma and amniotic fluid of patients with severe preeclampsia",
abstract = "OBJECTIVE: Our purpose was to investigate levels of fetal fibronectin in maternal plasma, amniotic fluid, and umbilical cord plasma from patients with severe preeclampsia. STUDY DESIGN: The study group comprised 20 patients with severe preeclampsia (group A). An antopartum comparison group was composed of 20 healthy patients matched for gestational age (group B). An intrapartum control group consisted of 20 term normotensive patients (group C). Maternal plasma samples were collected before labor (groups A and B), then immediately after delivery, and again at 20 to 24 hours post partum (groups A and C). Amniotic fluid was also collected in early labor, and umbilical cord blood was collected at delivery (groups A and C). Samples were assayed for fetal fibronectin by a specific enzyme-linked immunoassay. RESULTS: Before labor maternal plasma levels of fetal fibronectin were significantly elevated in preeclamptic patients compared with patients in group B (p < 0.0001). Plasma levels of fetal fibronectin were also increased in preeclamptic patients compared with patients in group C at delivery (p < 0.0001) and post partum (p < 0.05). Additionally, amniotic fluid levels of fetal fibronectin in the preeclamptic patients were significantly increased (p < 0.05). In contrast, umbilical cord plasma fetal fibronectin concentrations from the preeclamptic and control patients were similar. CONCLUSIONS: Fetal fibronectin is elevated in the maternal plasma and amniotic fluid, but not umbilical cord plasma, of patients with severe preeclampsia. These findings suggest an increase in production of fetal fibronectin from chorionic trophoblasts in patients with preeclampsia or an abnormal interaction between chorionic trophoblast and decidua with reusltant increased leakage into the maternal circulation and amniotic fluid.",
keywords = "Preeclampsia, amniotic fluid, fetal fibronectin, plasma",
author = "Kupfermine, {Michael J.} and Peaceman, {Alan M} and Wigton, {Thomas R.} and Rehnberg, {Karen A.} and Socol, {Michael L}",
year = "1995",
month = "1",
day = "1",
doi = "10.1016/0002-9378(95)90587-1",
language = "English (US)",
volume = "172",
pages = "649--653",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "2 PART 1",

}

Fetal fibronectin levels are elevated in maternal plasma and amniotic fluid of patients with severe preeclampsia. / Kupfermine, Michael J.; Peaceman, Alan M; Wigton, Thomas R.; Rehnberg, Karen A.; Socol, Michael L.

In: American Journal of Obstetrics and Gynecology, Vol. 172, No. 2 PART 1, 01.01.1995, p. 649-653.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Fetal fibronectin levels are elevated in maternal plasma and amniotic fluid of patients with severe preeclampsia

AU - Kupfermine, Michael J.

AU - Peaceman, Alan M

AU - Wigton, Thomas R.

AU - Rehnberg, Karen A.

AU - Socol, Michael L

PY - 1995/1/1

Y1 - 1995/1/1

N2 - OBJECTIVE: Our purpose was to investigate levels of fetal fibronectin in maternal plasma, amniotic fluid, and umbilical cord plasma from patients with severe preeclampsia. STUDY DESIGN: The study group comprised 20 patients with severe preeclampsia (group A). An antopartum comparison group was composed of 20 healthy patients matched for gestational age (group B). An intrapartum control group consisted of 20 term normotensive patients (group C). Maternal plasma samples were collected before labor (groups A and B), then immediately after delivery, and again at 20 to 24 hours post partum (groups A and C). Amniotic fluid was also collected in early labor, and umbilical cord blood was collected at delivery (groups A and C). Samples were assayed for fetal fibronectin by a specific enzyme-linked immunoassay. RESULTS: Before labor maternal plasma levels of fetal fibronectin were significantly elevated in preeclamptic patients compared with patients in group B (p < 0.0001). Plasma levels of fetal fibronectin were also increased in preeclamptic patients compared with patients in group C at delivery (p < 0.0001) and post partum (p < 0.05). Additionally, amniotic fluid levels of fetal fibronectin in the preeclamptic patients were significantly increased (p < 0.05). In contrast, umbilical cord plasma fetal fibronectin concentrations from the preeclamptic and control patients were similar. CONCLUSIONS: Fetal fibronectin is elevated in the maternal plasma and amniotic fluid, but not umbilical cord plasma, of patients with severe preeclampsia. These findings suggest an increase in production of fetal fibronectin from chorionic trophoblasts in patients with preeclampsia or an abnormal interaction between chorionic trophoblast and decidua with reusltant increased leakage into the maternal circulation and amniotic fluid.

AB - OBJECTIVE: Our purpose was to investigate levels of fetal fibronectin in maternal plasma, amniotic fluid, and umbilical cord plasma from patients with severe preeclampsia. STUDY DESIGN: The study group comprised 20 patients with severe preeclampsia (group A). An antopartum comparison group was composed of 20 healthy patients matched for gestational age (group B). An intrapartum control group consisted of 20 term normotensive patients (group C). Maternal plasma samples were collected before labor (groups A and B), then immediately after delivery, and again at 20 to 24 hours post partum (groups A and C). Amniotic fluid was also collected in early labor, and umbilical cord blood was collected at delivery (groups A and C). Samples were assayed for fetal fibronectin by a specific enzyme-linked immunoassay. RESULTS: Before labor maternal plasma levels of fetal fibronectin were significantly elevated in preeclamptic patients compared with patients in group B (p < 0.0001). Plasma levels of fetal fibronectin were also increased in preeclamptic patients compared with patients in group C at delivery (p < 0.0001) and post partum (p < 0.05). Additionally, amniotic fluid levels of fetal fibronectin in the preeclamptic patients were significantly increased (p < 0.05). In contrast, umbilical cord plasma fetal fibronectin concentrations from the preeclamptic and control patients were similar. CONCLUSIONS: Fetal fibronectin is elevated in the maternal plasma and amniotic fluid, but not umbilical cord plasma, of patients with severe preeclampsia. These findings suggest an increase in production of fetal fibronectin from chorionic trophoblasts in patients with preeclampsia or an abnormal interaction between chorionic trophoblast and decidua with reusltant increased leakage into the maternal circulation and amniotic fluid.

KW - Preeclampsia

KW - amniotic fluid

KW - fetal fibronectin

KW - plasma

UR - http://www.scopus.com/inward/record.url?scp=0028963790&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028963790&partnerID=8YFLogxK

U2 - 10.1016/0002-9378(95)90587-1

DO - 10.1016/0002-9378(95)90587-1

M3 - Article

VL - 172

SP - 649

EP - 653

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 2 PART 1

ER -