Fetal thrombotic vasculopathy in twin placentas with complete hydatidiform mole

Linda M. Ernst, Doris Chou, Samuel Parry

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Complete hydatidiform mole with a coexistent normal twin is rare, but the mortality rate for the coexistent twin is high, usually attributed to preeclampsia or vaginal bleeding. Placental examination of 3 twin pregnancies complicated by complete hydatidiform mole revealed significant abnormalities in the fetal vasculature. In 1 case, an intrauterine demise at 27 weeks, the placenta showed chorionic plate vessels with mural fibrin thrombi. The placenta from a second case, delivered at 30 weeks for preterm labor, showed similar thrombi in chorionic plate vessels, accompanied by calcification. A third case delivered at 35 weeks produced a liveborn infant, and the placenta showed villous stromal-vascular karyorrhexis, avascular villi, and stem villous thrombosis. Fetal placental thrombotic lesions seen in the coexistent twin circulation, associated with a complete hydatidiform mole, may play a heretofore unrecognized role in the morbidity and mortality of the fetus.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalPediatric and Developmental Pathology
Issue number1
StatePublished - Jan 2009


  • Avascular villi
  • Fetal thrombotic vasculopathy
  • Molar twin
  • Villous stromal-vascular karyorrhexis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine


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