FGF23 and Nutritional Metabolism

Lindsay R. Pool, Myles Wolf

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


The discovery of fibroblast growth factor 23 (FGF23) has provided a more complete understanding of the regulation of phosphate and mineral homeostasis in health and in chronic kidney disease. It has also offered new insights into stratification of risk of cardiovascular events and death among patients with chronic kidney disease and the general population. In this review, we provide an overview of FGF23 biology and physiology, summarize clinical outcomes that have been associated with FGF23, discuss potential mechanisms for these observations and their public health implications, and explore clinical and population health interventions that aim to reduce FGF23 levels and improve public health.

Original languageEnglish (US)
Pages (from-to)247-268
Number of pages22
JournalAnnual Review of Nutrition
StatePublished - Aug 21 2017
Externally publishedYes


  • Cardiovascular disease
  • Chronic kidney disease
  • Fibroblast growth factor 23
  • Nutritional metabolism
  • Phosphate

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Medicine (miscellaneous)


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