TY - JOUR
T1 - FGF23 and Nutritional Metabolism
AU - Pool, Lindsay R.
AU - Wolf, Myles
N1 - Funding Information:
This work was supported in part by a grant from the American Heart Association (15SFDRN25080331).
Funding Information:
Dr. Wolf has served as a consultant or received honoraria from Amag, Amgen, Ardelyx, DiaSorin, Incyte, Keryx, Lilly, Pfizer, Sanofi, Ultragenyx, and ZS Pharma, and received grant support from Shire.
Publisher Copyright:
© 2017 by Annual Reviews.
PY - 2017/8/21
Y1 - 2017/8/21
N2 - The discovery of fibroblast growth factor 23 (FGF23) has provided a more complete understanding of the regulation of phosphate and mineral homeostasis in health and in chronic kidney disease. It has also offered new insights into stratification of risk of cardiovascular events and death among patients with chronic kidney disease and the general population. In this review, we provide an overview of FGF23 biology and physiology, summarize clinical outcomes that have been associated with FGF23, discuss potential mechanisms for these observations and their public health implications, and explore clinical and population health interventions that aim to reduce FGF23 levels and improve public health.
AB - The discovery of fibroblast growth factor 23 (FGF23) has provided a more complete understanding of the regulation of phosphate and mineral homeostasis in health and in chronic kidney disease. It has also offered new insights into stratification of risk of cardiovascular events and death among patients with chronic kidney disease and the general population. In this review, we provide an overview of FGF23 biology and physiology, summarize clinical outcomes that have been associated with FGF23, discuss potential mechanisms for these observations and their public health implications, and explore clinical and population health interventions that aim to reduce FGF23 levels and improve public health.
KW - Cardiovascular disease
KW - Chronic kidney disease
KW - Fibroblast growth factor 23
KW - Nutritional metabolism
KW - Phosphate
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U2 - 10.1146/annurev-nutr-071816-064620
DO - 10.1146/annurev-nutr-071816-064620
M3 - Review article
C2 - 28715994
AN - SCOPUS:85027986320
VL - 37
SP - 247
EP - 268
JO - Annual Review of Nutrition
JF - Annual Review of Nutrition
SN - 0199-9885
ER -
