FGF23 or PTH: Which comes first in CKD

Tamara Isakova, Myles S. Wolf

Research output: Contribution to journalComment/debatepeer-review

61 Scopus citations


In the past 40 years, disordered mineral metabolism has been among the most intensely studied areas of nephrology. A June 2010 PubMed search for secondary hyperparathyroidism and kidney disease yielded 5866 references. Among these are papers documenting the development and application of numerous therapeutic agentsincluding calcitriol, vitamin D analogs, phosphate binders, and cinacalcetthat remain in widespread use in the day-to-day management of dialysis patients worldwide. However, almost 6000 papers later, fundamental pathophysiological concepts remain unclear, particularly regarding the early pathogenesis of disordered mineral metabolism.

Original languageEnglish (US)
Pages (from-to)947-949
Number of pages3
JournalKidney international
Issue number10
StatePublished - Nov 2010

ASJC Scopus subject areas

  • Nephrology


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