FGFR3-TACC3 fusion in solid tumors: Mini review

Ricardo Costa*, Benedito A. Carneiro, Timothy Taxter, Fabio A. Tavora, Aparna Kalyan, Sachin A. Pai, Young Kwang Chae, Francis J. Giles

*Corresponding author for this work

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Fibroblast growth factor receptors (FGFR) are transmembrane kinase proteins with growing importance in cancer biology given the frequency of molecular alterations and vast interface with multiple other signaling pathways. Furthermore, numerous FGFR inhibitors in clinical development demonstrate the expanding therapeutic relevance of this pathway. Indeed, results from early phase clinical trials already indicate that a subset of patients with advanced tumors derive benefit from FGFR targeted therapies. FGFR gene aberrations and FGFR gene rearrangements are relatively rare in solid malignancies. The recently described FGFR3-TACC3 fusion protein has a constitutively active tyrosine kinase domain and promotes aneuploidy. We summarize the prevalence data on FGFR3-TACC3 fusions among different histological tumor types and the preliminary evidence that this rearrangement represents a targetable molecular aberration in some patients with solid tumors.

Original languageEnglish (US)
Pages (from-to)55924-55938
Number of pages15
JournalOncotarget
Volume7
Issue number34
DOIs
StatePublished - 2016

Keywords

  • Aneuploidy
  • FGFR3-TACC3 fusion
  • Glioblastoma multiforme
  • Non-small cell lung cancer
  • Phosphatidylinositol 3-Kinase (PI3K)

ASJC Scopus subject areas

  • Oncology

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    Costa, R., Carneiro, B. A., Taxter, T., Tavora, F. A., Kalyan, A., Pai, S. A., Chae, Y. K., & Giles, F. J. (2016). FGFR3-TACC3 fusion in solid tumors: Mini review. Oncotarget, 7(34), 55924-55938. https://doi.org/10.18632/oncotarget.10482