Fibrin generation in normal pregnancy

Carl P. Weiner*, Hau Kwaan, Walter W. Hauck, Fred J. Duboe, Michael Paul, Carl Bertil Wallemark

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Both clinical and laboratory findings suggest that pregnancy constitutes a hypercoagulable condition; yet none of the observed laboratory changes are specific for thrombosis. An essential step involves thrombin-mediated fibrin generation. In the process, fibrinopeptide A (FPA) is cleaved from fibrinogen. Using a radioimmune assay, FPA was determined prospectively in a longitudinal and cross-sectional fashion. Fibrinopeptide A increased significantly over control by the end of the first trimester, from 1.3 ng/ml to 2.8 ng/ml. It continued to increase until 30 to 32 weeks' gestation and then plateaued at 4.3 to 4.7 ng/ml. In the immediate postpartum period, FPA remains elevated. In conclusion, thrombin generation as reflected in FPA production is increased throughout pregnancy, thus confirming a hypercoagulable milieu.

Original languageEnglish (US)
Pages (from-to)46-48
Number of pages3
JournalObstetrics and gynecology
Issue number1
StatePublished - Jul 1984

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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