Fibrinogen adsorbs from aqueous media to microscopic droplets of poly(dimethylsiloxane) and remains coagulable

Patrick W. Whitlock, Stephen J. Clarson, Gregory S. Retzinger*

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Fibrinogen binds from aqueous media containing it to droplets of linear trimethylsilyl-terminated poly(dimethylsiloxane) (PDMS) dispersed in those same media. Once bound, fibrinogen elutes from emulsified droplets of PDMS only very slowly, even when incubated in buffer that contains a physiologic concentration of the protein. The bound fibrinogen is coagulable, as indicated by the thrombin-dependent agglutination of droplets. Thus fibrinogen bound to droplets of PDMS renders an adhesive potential to the surface of the droplets, a potential that may have relevance to the biologic processing of the polymer in vivo.

Original languageEnglish (US)
Pages (from-to)55-61
Number of pages7
JournalJournal of Biomedical Materials Research
Volume45
Issue number1
DOIs
StatePublished - Apr 1999

Keywords

  • Adhesion
  • Adjuvancy
  • Fibrinogen
  • Inflammation
  • Poly(dimethylsiloxane)

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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