Fibrinolytic activity in the normal and inflamed rectal mucosa

H. C. Kwaan*, A. Cocco, A. I. Mendeloff, T. Astrup

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


In an attempt to determine whether an abnormal hemostatic mechanism may account for mucosal friability in active ulcerative colitis, rectal biopsy specimens from normal subjects and from patients with ulcerative colitis, or other inflammatory or radiation-induced disorders of the colon, were studied for fibrinolytic activity by the histochemical fibrin slide technique. Fibrinolytically active sites occurred more frequently in specimens from patients with active ulcerative colitis than in normal specimens. Plasminogen activator was present at sites in the edematous lamina propria.

Original languageEnglish (US)
Pages (from-to)441-445
Number of pages5
JournalScandinavian Journal of Gastroenterology
Issue number5
StatePublished - 1969


  • Colitis, ulcerative
  • Colon
  • Enteritis
  • Fibrinolysis
  • Intestine, large
  • Proctitis

ASJC Scopus subject areas

  • Gastroenterology


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