Fibrosis, portal hypertension, and hepatic volume changes induced by intra-arterial radiotherapy with 90Yttrium microspheres

T. F. Jakobs, S. Saleem, B. Atassi, E. Reda, R. J. Lewandowski, V. Yaghmai, F. Miller, R. K. Ryu, S. Ibrahim, K. T. Sato, L. M. Kulik, M. F. Mulcahy, R. Omary, R. Murthy, M. F. Reiser, R. Salem*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

96 Scopus citations


Purpose: To identify changes in hepatic parenchymal volume, fibrosis, and induction of portal hypertension following radioembolization with glass microspheres for patients with metastatic disease to the liver. Results: In our series of sequential bilobar (n = 17) treatments, a mean decrease in liver volume of 11.8% was noted. In this group, a mean splenic volume increase of 27.9% and portal vein diameter increase of 4.8% were noted. For patients receiving unilobar treatments (n = 15), mean ipsilateral lobar volume decrease of 8.9%, contralateral lobar hypertrophy of 21.2%, and a 5.4% increase in portal vein diameter were also noted. These findings were not associated with clinical toxicities. Conclusion: 90Yttrium radioembolization utilizing glass microspheres in patients with liver metastases results in changes of hepatic parenchymal volume and also induced findings suggestive of fibrosis and portal hypertension. Further studies assessing the long-term effects are warranted.

Original languageEnglish (US)
Pages (from-to)2556-2563
Number of pages8
JournalDigestive diseases and sciences
Issue number9
StatePublished - Sep 2008


  • Fibrosis
  • Liver metastases
  • Palliative treatment
  • Portal hypertension
  • Radiation-induced liver disease
  • Radioembolization

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology


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