Fibrosis, portal hypertension, and hepatic volume changes induced by intra-arterial radiotherapy with 90Yttrium microspheres

T. F. Jakobs, S. Saleem, B. Atassi, E. Reda, R. J. Lewandowski, V. Yaghmai, F. Miller, R. K. Ryu, S. Ibrahim, K. T. Sato, L. M. Kulik, M. F. Mulcahy, R. Omary, R. Murthy, M. F. Reiser, R. Salem*

*Corresponding author for this work

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Purpose: To identify changes in hepatic parenchymal volume, fibrosis, and induction of portal hypertension following radioembolization with glass microspheres for patients with metastatic disease to the liver. Results: In our series of sequential bilobar (n = 17) treatments, a mean decrease in liver volume of 11.8% was noted. In this group, a mean splenic volume increase of 27.9% and portal vein diameter increase of 4.8% were noted. For patients receiving unilobar treatments (n = 15), mean ipsilateral lobar volume decrease of 8.9%, contralateral lobar hypertrophy of 21.2%, and a 5.4% increase in portal vein diameter were also noted. These findings were not associated with clinical toxicities. Conclusion: 90Yttrium radioembolization utilizing glass microspheres in patients with liver metastases results in changes of hepatic parenchymal volume and also induced findings suggestive of fibrosis and portal hypertension. Further studies assessing the long-term effects are warranted.

Original languageEnglish (US)
Pages (from-to)2556-2563
Number of pages8
JournalDigestive diseases and sciences
Volume53
Issue number9
DOIs
StatePublished - Sep 1 2008

Fingerprint

Portal Hypertension
Microspheres
Fibrosis
Radiotherapy
Liver
Portal Vein
Glass
Hypertrophy
Liver Diseases
Neoplasm Metastasis
Therapeutics

Keywords

  • Fibrosis
  • Liver metastases
  • Palliative treatment
  • Portal hypertension
  • Radiation-induced liver disease
  • Radioembolization

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Jakobs, T. F. ; Saleem, S. ; Atassi, B. ; Reda, E. ; Lewandowski, R. J. ; Yaghmai, V. ; Miller, F. ; Ryu, R. K. ; Ibrahim, S. ; Sato, K. T. ; Kulik, L. M. ; Mulcahy, M. F. ; Omary, R. ; Murthy, R. ; Reiser, M. F. ; Salem, R. / Fibrosis, portal hypertension, and hepatic volume changes induced by intra-arterial radiotherapy with 90Yttrium microspheres. In: Digestive diseases and sciences. 2008 ; Vol. 53, No. 9. pp. 2556-2563.
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abstract = "Purpose: To identify changes in hepatic parenchymal volume, fibrosis, and induction of portal hypertension following radioembolization with glass microspheres for patients with metastatic disease to the liver. Results: In our series of sequential bilobar (n = 17) treatments, a mean decrease in liver volume of 11.8{\%} was noted. In this group, a mean splenic volume increase of 27.9{\%} and portal vein diameter increase of 4.8{\%} were noted. For patients receiving unilobar treatments (n = 15), mean ipsilateral lobar volume decrease of 8.9{\%}, contralateral lobar hypertrophy of 21.2{\%}, and a 5.4{\%} increase in portal vein diameter were also noted. These findings were not associated with clinical toxicities. Conclusion: 90Yttrium radioembolization utilizing glass microspheres in patients with liver metastases results in changes of hepatic parenchymal volume and also induced findings suggestive of fibrosis and portal hypertension. Further studies assessing the long-term effects are warranted.",
keywords = "Fibrosis, Liver metastases, Palliative treatment, Portal hypertension, Radiation-induced liver disease, Radioembolization",
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Fibrosis, portal hypertension, and hepatic volume changes induced by intra-arterial radiotherapy with 90Yttrium microspheres. / Jakobs, T. F.; Saleem, S.; Atassi, B.; Reda, E.; Lewandowski, R. J.; Yaghmai, V.; Miller, F.; Ryu, R. K.; Ibrahim, S.; Sato, K. T.; Kulik, L. M.; Mulcahy, M. F.; Omary, R.; Murthy, R.; Reiser, M. F.; Salem, R.

In: Digestive diseases and sciences, Vol. 53, No. 9, 01.09.2008, p. 2556-2563.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Fibrosis, portal hypertension, and hepatic volume changes induced by intra-arterial radiotherapy with 90Yttrium microspheres

AU - Jakobs, T. F.

AU - Saleem, S.

AU - Atassi, B.

AU - Reda, E.

AU - Lewandowski, R. J.

AU - Yaghmai, V.

AU - Miller, F.

AU - Ryu, R. K.

AU - Ibrahim, S.

AU - Sato, K. T.

AU - Kulik, L. M.

AU - Mulcahy, M. F.

AU - Omary, R.

AU - Murthy, R.

AU - Reiser, M. F.

AU - Salem, R.

PY - 2008/9/1

Y1 - 2008/9/1

N2 - Purpose: To identify changes in hepatic parenchymal volume, fibrosis, and induction of portal hypertension following radioembolization with glass microspheres for patients with metastatic disease to the liver. Results: In our series of sequential bilobar (n = 17) treatments, a mean decrease in liver volume of 11.8% was noted. In this group, a mean splenic volume increase of 27.9% and portal vein diameter increase of 4.8% were noted. For patients receiving unilobar treatments (n = 15), mean ipsilateral lobar volume decrease of 8.9%, contralateral lobar hypertrophy of 21.2%, and a 5.4% increase in portal vein diameter were also noted. These findings were not associated with clinical toxicities. Conclusion: 90Yttrium radioembolization utilizing glass microspheres in patients with liver metastases results in changes of hepatic parenchymal volume and also induced findings suggestive of fibrosis and portal hypertension. Further studies assessing the long-term effects are warranted.

AB - Purpose: To identify changes in hepatic parenchymal volume, fibrosis, and induction of portal hypertension following radioembolization with glass microspheres for patients with metastatic disease to the liver. Results: In our series of sequential bilobar (n = 17) treatments, a mean decrease in liver volume of 11.8% was noted. In this group, a mean splenic volume increase of 27.9% and portal vein diameter increase of 4.8% were noted. For patients receiving unilobar treatments (n = 15), mean ipsilateral lobar volume decrease of 8.9%, contralateral lobar hypertrophy of 21.2%, and a 5.4% increase in portal vein diameter were also noted. These findings were not associated with clinical toxicities. Conclusion: 90Yttrium radioembolization utilizing glass microspheres in patients with liver metastases results in changes of hepatic parenchymal volume and also induced findings suggestive of fibrosis and portal hypertension. Further studies assessing the long-term effects are warranted.

KW - Fibrosis

KW - Liver metastases

KW - Palliative treatment

KW - Portal hypertension

KW - Radiation-induced liver disease

KW - Radioembolization

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