Fibrosis, portal hypertension, and hepatic volume changes induced by intra-arterial radiotherapy with 90Yttrium microspheres

T. F. Jakobs; S. Saleem; B. Atassi; E. Reda; R. J. Lewandowski; V. Yaghmai; F. Miller; R. K. Ryu; S. Ibrahim; K. T. Sato; L. M. Kulik; M. F. Mulcahy; R. Omary; R. Murthy; M. F. Reiser; R. Salem

doi:10.1007/s10620-007-0148-z

Fibrosis, portal hypertension, and hepatic volume changes induced by intra-arterial radiotherapy with ⁹⁰Yttrium microspheres

T. F. Jakobs, S. Saleem, B. Atassi, E. Reda, R. J. Lewandowski, V. Yaghmai, F. Miller, R. K. Ryu, S. Ibrahim, K. T. Sato, L. M. Kulik, M. F. Mulcahy, R. Omary, R. Murthy, M. F. Reiser, R. Salem^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

123 Scopus citations

Abstract

Purpose: To identify changes in hepatic parenchymal volume, fibrosis, and induction of portal hypertension following radioembolization with glass microspheres for patients with metastatic disease to the liver. Results: In our series of sequential bilobar (n = 17) treatments, a mean decrease in liver volume of 11.8% was noted. In this group, a mean splenic volume increase of 27.9% and portal vein diameter increase of 4.8% were noted. For patients receiving unilobar treatments (n = 15), mean ipsilateral lobar volume decrease of 8.9%, contralateral lobar hypertrophy of 21.2%, and a 5.4% increase in portal vein diameter were also noted. These findings were not associated with clinical toxicities. Conclusion: ⁹⁰Yttrium radioembolization utilizing glass microspheres in patients with liver metastases results in changes of hepatic parenchymal volume and also induced findings suggestive of fibrosis and portal hypertension. Further studies assessing the long-term effects are warranted.

Original language	English (US)
Pages (from-to)	2556-2563
Number of pages	8
Journal	Digestive diseases and sciences
Volume	53
Issue number	9
DOIs	https://doi.org/10.1007/s10620-007-0148-z
State	Published - Sep 2008

Funding

Acknowledgments Disclosure RS is a consultant for MDS Nordion. MFM receives grant support from MDS Nordion.

Keywords

Fibrosis
Liver metastases
Palliative treatment
Portal hypertension
Radiation-induced liver disease
Radioembolization

ASJC Scopus subject areas

Physiology
Gastroenterology

Access to Document

10.1007/s10620-007-0148-z

Cite this

Jakobs, T. F., Saleem, S., Atassi, B., Reda, E., Lewandowski, R. J., Yaghmai, V., Miller, F., Ryu, R. K., Ibrahim, S., Sato, K. T., Kulik, L. M., Mulcahy, M. F., Omary, R., Murthy, R., Reiser, M. F., & Salem, R. (2008). Fibrosis, portal hypertension, and hepatic volume changes induced by intra-arterial radiotherapy with ⁹⁰Yttrium microspheres. Digestive diseases and sciences, 53(9), 2556-2563. https://doi.org/10.1007/s10620-007-0148-z

@article{f1b4bf3f83a841c8b541c60acabf15a6,

title = "Fibrosis, portal hypertension, and hepatic volume changes induced by intra-arterial radiotherapy with 90Yttrium microspheres",

abstract = "Purpose: To identify changes in hepatic parenchymal volume, fibrosis, and induction of portal hypertension following radioembolization with glass microspheres for patients with metastatic disease to the liver. Results: In our series of sequential bilobar (n = 17) treatments, a mean decrease in liver volume of 11.8% was noted. In this group, a mean splenic volume increase of 27.9% and portal vein diameter increase of 4.8% were noted. For patients receiving unilobar treatments (n = 15), mean ipsilateral lobar volume decrease of 8.9%, contralateral lobar hypertrophy of 21.2%, and a 5.4% increase in portal vein diameter were also noted. These findings were not associated with clinical toxicities. Conclusion: 90Yttrium radioembolization utilizing glass microspheres in patients with liver metastases results in changes of hepatic parenchymal volume and also induced findings suggestive of fibrosis and portal hypertension. Further studies assessing the long-term effects are warranted.",

keywords = "Fibrosis, Liver metastases, Palliative treatment, Portal hypertension, Radiation-induced liver disease, Radioembolization",

author = "Jakobs, {T. F.} and S. Saleem and B. Atassi and E. Reda and Lewandowski, {R. J.} and V. Yaghmai and F. Miller and Ryu, {R. K.} and S. Ibrahim and Sato, {K. T.} and Kulik, {L. M.} and Mulcahy, {M. F.} and R. Omary and R. Murthy and Reiser, {M. F.} and R. Salem",

note = "Funding Information: Acknowledgments Disclosure RS is a consultant for MDS Nordion. MFM receives grant support from MDS Nordion.",

year = "2008",

month = sep,

doi = "10.1007/s10620-007-0148-z",

language = "English (US)",

volume = "53",

pages = "2556--2563",

journal = "Digestive diseases and sciences",

issn = "0163-2116",

publisher = "Springer",

number = "9",

}

Jakobs, TF, Saleem, S, Atassi, B, Reda, E, Lewandowski, RJ, Yaghmai, V, Miller, F, Ryu, RK, Ibrahim, S, Sato, KT , Kulik, LM , Mulcahy, MF, Omary, R, Murthy, R, Reiser, MF & Salem, R 2008, 'Fibrosis, portal hypertension, and hepatic volume changes induced by intra-arterial radiotherapy with ⁹⁰Yttrium microspheres', Digestive diseases and sciences, vol. 53, no. 9, pp. 2556-2563. https://doi.org/10.1007/s10620-007-0148-z

TY - JOUR

T1 - Fibrosis, portal hypertension, and hepatic volume changes induced by intra-arterial radiotherapy with 90Yttrium microspheres

AU - Jakobs, T. F.

AU - Saleem, S.

AU - Atassi, B.

AU - Reda, E.

AU - Lewandowski, R. J.

AU - Yaghmai, V.

AU - Miller, F.

AU - Ryu, R. K.

AU - Ibrahim, S.

AU - Sato, K. T.

AU - Kulik, L. M.

AU - Mulcahy, M. F.

AU - Omary, R.

AU - Murthy, R.

AU - Reiser, M. F.

AU - Salem, R.

N1 - Funding Information: Acknowledgments Disclosure RS is a consultant for MDS Nordion. MFM receives grant support from MDS Nordion.

PY - 2008/9

Y1 - 2008/9

N2 - Purpose: To identify changes in hepatic parenchymal volume, fibrosis, and induction of portal hypertension following radioembolization with glass microspheres for patients with metastatic disease to the liver. Results: In our series of sequential bilobar (n = 17) treatments, a mean decrease in liver volume of 11.8% was noted. In this group, a mean splenic volume increase of 27.9% and portal vein diameter increase of 4.8% were noted. For patients receiving unilobar treatments (n = 15), mean ipsilateral lobar volume decrease of 8.9%, contralateral lobar hypertrophy of 21.2%, and a 5.4% increase in portal vein diameter were also noted. These findings were not associated with clinical toxicities. Conclusion: 90Yttrium radioembolization utilizing glass microspheres in patients with liver metastases results in changes of hepatic parenchymal volume and also induced findings suggestive of fibrosis and portal hypertension. Further studies assessing the long-term effects are warranted.

AB - Purpose: To identify changes in hepatic parenchymal volume, fibrosis, and induction of portal hypertension following radioembolization with glass microspheres for patients with metastatic disease to the liver. Results: In our series of sequential bilobar (n = 17) treatments, a mean decrease in liver volume of 11.8% was noted. In this group, a mean splenic volume increase of 27.9% and portal vein diameter increase of 4.8% were noted. For patients receiving unilobar treatments (n = 15), mean ipsilateral lobar volume decrease of 8.9%, contralateral lobar hypertrophy of 21.2%, and a 5.4% increase in portal vein diameter were also noted. These findings were not associated with clinical toxicities. Conclusion: 90Yttrium radioembolization utilizing glass microspheres in patients with liver metastases results in changes of hepatic parenchymal volume and also induced findings suggestive of fibrosis and portal hypertension. Further studies assessing the long-term effects are warranted.

KW - Fibrosis

KW - Liver metastases

KW - Palliative treatment

KW - Portal hypertension

KW - Radiation-induced liver disease

KW - Radioembolization

UR - http://www.scopus.com/inward/record.url?scp=50249130786&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50249130786&partnerID=8YFLogxK

U2 - 10.1007/s10620-007-0148-z

DO - 10.1007/s10620-007-0148-z

M3 - Article

C2 - 18231857

AN - SCOPUS:50249130786

SN - 0163-2116

VL - 53

SP - 2556

EP - 2563

JO - Digestive diseases and sciences

JF - Digestive diseases and sciences

IS - 9

ER -