TY - JOUR
T1 - Fibrous Dysplasia Mimicking Malignancy on 68Ga-DOTATATE PET/CT
AU - Papadakis, Georgios Z.
AU - Millo, Corina
AU - Sadowski, Samira M.
AU - Karantanas, Apostolos H.
AU - Bagci, Ulas
AU - Patronas, Nicholas J.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Fibrous dysplasia of the bone is a developmental benign skeletal disorder characterized by replacement of normal bone and normal bone marrow with abnormal fibro-osseous tissue. We report on a case of a biopsy-proven fibrous dysplasia lesion in the left temporal bone, with intensely increased activity (SUVmax, 56.7) on Ga-DOTATATE PET/CT. The presented data indicate cell surface overexpression of somatostatin receptors by fibrous dysplastic cells and highlight the need of cautious management of Ga-DOTATATE-avid bone lesions, which could mimic malignancy especially in patients with history of neuroendocrine tumors.
AB - Fibrous dysplasia of the bone is a developmental benign skeletal disorder characterized by replacement of normal bone and normal bone marrow with abnormal fibro-osseous tissue. We report on a case of a biopsy-proven fibrous dysplasia lesion in the left temporal bone, with intensely increased activity (SUVmax, 56.7) on Ga-DOTATATE PET/CT. The presented data indicate cell surface overexpression of somatostatin receptors by fibrous dysplastic cells and highlight the need of cautious management of Ga-DOTATATE-avid bone lesions, which could mimic malignancy especially in patients with history of neuroendocrine tumors.
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U2 - 10.1097/RLU.0000000000001527
DO - 10.1097/RLU.0000000000001527
M3 - Article
C2 - 28072620
AN - SCOPUS:85027940321
VL - 42
SP - 209
EP - 210
JO - Clinical Nuclear Medicine
JF - Clinical Nuclear Medicine
SN - 0363-9762
IS - 3
ER -