Fibrous Dysplasia Mimicking Malignancy on 68Ga-DOTATATE PET/CT

Georgios Z. Papadakis*, Corina Millo, Samira M. Sadowski, Apostolos H. Karantanas, Ulas Bagci, Nicholas J. Patronas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Fibrous dysplasia of the bone is a developmental benign skeletal disorder characterized by replacement of normal bone and normal bone marrow with abnormal fibro-osseous tissue. We report on a case of a biopsy-proven fibrous dysplasia lesion in the left temporal bone, with intensely increased activity (SUVmax, 56.7) on 68Ga-DOTATATE PET/CT. The presented data indicate cell surface overexpression of somatostatin receptors by fibrous dysplastic cells and highlight the need of cautious management of 68Ga-DOTATATE-avid bone lesions, which could mimic malignancy especially in patients with history of neuroendocrine tumors.

Original languageEnglish (US)
Pages (from-to)209-210
Number of pages2
JournalClinical nuclear medicine
Volume42
Issue number3
DOIs
StatePublished - Mar 1 2017
Externally publishedYes

Keywords

  • CT
  • Ga-DOTATATE PET/CT
  • MRI
  • fibrous dysplasia of bone
  • somatostatin receptors (SSTRs)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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