Fidaxomicin for the treatment of Clostridioides difficile in children

Andrew M. Skinner*, Tonya Scardina, Larry K. Kociolek

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Fidaxomicin is an oral narrow-spectrum novel 18-membered macrocyclic antibiotic that was initially approved in 2011 by the US FDA for the treatment of Clostridioides difficile infections (CDI) in adults. In February 2020, the FDA approved fidaxomicin for the treatment of CDI in children age >6 months. In adults, fidaxomicin is as efficacious as vancomycin in treating CDI and reduces the risk of recurrent CDI. An investigator-blinded, randomized, multicenter, multinational clinical trial comparing the efficacy and safety of fidaxomicin with vancomycin in children was recently published confirming similar findings as previously reported in adults. Fidaxomicin is the first FDA-approved treatment for CDI in children and offers a promising option for reducing recurrent CDI in this population.

Original languageEnglish (US)
Pages (from-to)967-979
Number of pages13
JournalFuture Microbiology
Volume15
Issue number11
DOIs
StatePublished - Jul 2020

Keywords

  • C. difficile
  • Clostridioides difficile
  • Gram-positive bacteria
  • antibiotics
  • fidaxomicin
  • gastrointestinal infections
  • infection
  • infectious disease therapeutics
  • pediatrics
  • pharmacokinetics/pharmacodynamics

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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