Fifth Edition of the World Health Organization Classification of Tumors of the Hematopoietic and Lymphoid Tissues: Mature T-Cell, NK-Cell, and Stroma-Derived Neoplasms of Lymphoid Tissues

WHO fifth edition classification project

Research output: Contribution to journalReview articlepeer-review

Abstract

This review focuses on mature T cells, natural killer (NK) cells, and stroma-derived neoplasms in the fifth edition of the World Health Organization classification of hematolymphoid tumors, including changes from the revised fourth edition. Overall, information has expanded, primarily due to advancements in genomic understanding. The updated classification adopts a hierarchical format. The updated classification relies on a multidisciplinary approach, incorporating insights from a diverse group of pathologists, clinicians, and geneticists. Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract, Epstein–Barr virus-positive nodal T- and NK-cell lymphoma, and several stroma-derived neoplasms of lymphoid tissues have been newly introduced or included. The review also provides guidance on how the fifth edition of the World Health Organization classification of hematolymphoid tumors can be applied in routine clinical practice.

Original languageEnglish (US)
Article number100512
JournalModern Pathology
Volume37
Issue number8
DOIs
StatePublished - Aug 2024

Keywords

  • Epstein–Barr virus
  • NK-cell leukemia
  • NK-cell lymphoma
  • T-cell leukemia
  • T-cell lymphoma
  • leukemia
  • lymphoma
  • stromal tumors of the lymphoid tissues

ASJC Scopus subject areas

  • General Medicine

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