Abstract
This review focuses on mature T cells, natural killer (NK) cells, and stroma-derived neoplasms in the fifth edition of the World Health Organization classification of hematolymphoid tumors, including changes from the revised fourth edition. Overall, information has expanded, primarily due to advancements in genomic understanding. The updated classification adopts a hierarchical format. The updated classification relies on a multidisciplinary approach, incorporating insights from a diverse group of pathologists, clinicians, and geneticists. Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract, Epstein–Barr virus-positive nodal T- and NK-cell lymphoma, and several stroma-derived neoplasms of lymphoid tissues have been newly introduced or included. The review also provides guidance on how the fifth edition of the World Health Organization classification of hematolymphoid tumors can be applied in routine clinical practice.
Original language | English (US) |
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Article number | 100512 |
Journal | Modern Pathology |
Volume | 37 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2024 |
Keywords
- Epstein–Barr virus
- NK-cell leukemia
- NK-cell lymphoma
- T-cell leukemia
- T-cell lymphoma
- leukemia
- lymphoma
- stromal tumors of the lymphoid tissues
ASJC Scopus subject areas
- General Medicine