Finding the maximum safe dose level for heteroscedastic data

Ajit C. Tamhane*, Brent R. Logan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

In this article we extend to the heteroscedastic setting the multiple stepwise test procedures proposed in Tamhane et al. [Tamhane. A. C., Dunnett, C. W., Green, J. W., Wetherington, J. F. (2001). Multiple test procedures for identifying a safe dose. J. Am. Statist. Assoc. 96:835-843] for finding the maximum safe dose. Toxicological data are often heteroscedastic; therefore, the extensions given herein should be highly useful in practice. Simulations are performed to study the Type I familywise error rate and power properties of the procedures. A real data example is given to illustrate the procedures.

Original languageEnglish (US)
Pages (from-to)843-856
Number of pages14
JournalJournal of Biopharmaceutical Statistics
Volume14
Issue number4
DOIs
StatePublished - 2004

Funding

This research was partially supported by an educational grant from DuPont. We thank Dr. John Green of DuPont Safety, Health and Environmental Excellence Center, Haskell Laboratory for Toxicology and Industrial Medicine for providing the data for the problem and helpful discussions. We also thank two referees for useful suggestions.

Keywords

  • Dose-response
  • Multiple comparisons
  • Toxicology
  • Unequal variances

ASJC Scopus subject areas

  • Statistics and Probability
  • Pharmacology
  • Pharmacology (medical)

Fingerprint

Dive into the research topics of 'Finding the maximum safe dose level for heteroscedastic data'. Together they form a unique fingerprint.

Cite this