Abstract
In this article we extend to the heteroscedastic setting the multiple stepwise test procedures proposed in Tamhane et al. [Tamhane. A. C., Dunnett, C. W., Green, J. W., Wetherington, J. F. (2001). Multiple test procedures for identifying a safe dose. J. Am. Statist. Assoc. 96:835-843] for finding the maximum safe dose. Toxicological data are often heteroscedastic; therefore, the extensions given herein should be highly useful in practice. Simulations are performed to study the Type I familywise error rate and power properties of the procedures. A real data example is given to illustrate the procedures.
Original language | English (US) |
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Pages (from-to) | 843-856 |
Number of pages | 14 |
Journal | Journal of Biopharmaceutical Statistics |
Volume | 14 |
Issue number | 4 |
DOIs | |
State | Published - 2004 |
Keywords
- Dose-response
- Multiple comparisons
- Toxicology
- Unequal variances
ASJC Scopus subject areas
- Statistics and Probability
- Pharmacology
- Pharmacology (medical)