Finding the maximum safe dose level for heteroscedastic data

Ajit C. Tamhane*, Brent R. Logan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


In this article we extend to the heteroscedastic setting the multiple stepwise test procedures proposed in Tamhane et al. [Tamhane. A. C., Dunnett, C. W., Green, J. W., Wetherington, J. F. (2001). Multiple test procedures for identifying a safe dose. J. Am. Statist. Assoc. 96:835-843] for finding the maximum safe dose. Toxicological data are often heteroscedastic; therefore, the extensions given herein should be highly useful in practice. Simulations are performed to study the Type I familywise error rate and power properties of the procedures. A real data example is given to illustrate the procedures.

Original languageEnglish (US)
Pages (from-to)843-856
Number of pages14
JournalJournal of Biopharmaceutical Statistics
Issue number4
StatePublished - 2004


  • Dose-response
  • Multiple comparisons
  • Toxicology
  • Unequal variances

ASJC Scopus subject areas

  • Statistics and Probability
  • Pharmacology
  • Pharmacology (medical)


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