Abstract
Antimicrobials have undoubtedly improved the lives of people with CF, but important antimicrobial-related toxicities and the emergence of antimicrobial-resistant bacteria associated with their use must be considered. Antimicrobial stewardship (AMS) is advocated across the spectrum of healthcare to promote the appropriate use of antimicrobials to preserve their current effectiveness and to optimise treatment, and it is clear that AMS strategies are applicable to and can benefit both non-CF and CF populations. This perspective explores the definition and components of an AMS program, the current evidence for AMS, and the reasons why AMS is a challenging concept in the provision of CF care. We also discuss the elements of CF care which align with AMS programs and principles and propose research priorities for AMS in CF.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 511-520 |
| Number of pages | 10 |
| Journal | Journal of Cystic Fibrosis |
| Volume | 19 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 2020 |
Funding
This work was funded by the European Cystic Fibrosis Society , Cystic Fibrosis Foundation , Cystic Fibrosis Trust , Cystic Fibrosis Canada , and Cystic Fibrosis Australia . Jonathan Cogen has funding from the CF Foundation (USA). Susanna McColley is supported, in part, by the National Center for Advancing Translational Sciences of the National Institutes of Health under Grant Number UL1TR001422 . Jason Roberts has funding from the Australian National Health and Medical Research Council for Centre of Research Excellence and Practitioner Fellowship. Alison Holmes is a National Institute for Health Research (NIHR) Senior Investigator. She also acknowledges the support of the NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance at Imperial College London. Patrick Flume is supported, in part, by the National Center for Advancing Translational Sciences of the National Institutes of Health under Grant Number UL1TR001450 . J. Stuart Elborn receives funding from the Innovative Medicines Initiative , Framework Seven, European Commission and from the Medical Research Council, UK . Lisa Saiman receives funding from the CF Foundation (USA). Scott Bell has funding from Australian National Health and Medical Research Council , the CF Foundation (USA) and the Queensland Children's Foundation . This work was funded by the European Cystic Fibrosis Society, Cystic Fibrosis Foundation, Cystic Fibrosis Trust, Cystic Fibrosis Canada, and Cystic Fibrosis Australia. Jonathan Cogen has funding from the CF Foundation (USA). Susanna McColley is supported, in part, by the National Center for Advancing Translational Sciences of the National Institutes of Health under Grant Number UL1TR001422. Jason Roberts has funding from the Australian National Health and Medical Research Council for Centre of Research Excellence and Practitioner Fellowship. Alison Holmes is a National Institute for Health Research (NIHR) Senior Investigator. She also acknowledges the support of the NIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance at Imperial College London. Patrick Flume is supported, in part, by the National Center for Advancing Translational Sciences of the National Institutes of Health under Grant Number UL1TR001450. J. Stuart Elborn receives funding from the Innovative Medicines Initiative, Framework Seven, European Commission and from the Medical Research Council, UK. Lisa Saiman receives funding from the CF Foundation (USA). Scott Bell has funding from Australian National Health and Medical Research Council, the CF Foundation (USA) and the Queensland Children's Foundation.This work was funded by the European Cystic Fibrosis Society, Cystic Fibrosis Foundation, Cystic Fibrosis Trust, Cystic Fibrosis Canada, and Cystic Fibrosis Australia. We are grateful to Christine Dubois for managing the coordination of the Antimicrobial Resistance International Working Group in Cystic Fibrosis and Mary Philips, Metro North Hospital and Health Service for her illustration skills. This work was funded by the European Cystic Fibrosis Society , Cystic Fibrosis Foundation , Cystic Fibrosis Trust , Cystic Fibrosis Canada , and Cystic Fibrosis Australia . We are grateful to Christine Dubois for managing the coordination of the Antimicrobial Resistance International Working Group in Cystic Fibrosis and Mary Philips, Metro North Hospital and Health Service for her illustration skills.
Keywords
- Antimicrobial stewardship
- Antimicrobials
- Pulmonary Exacerbations
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Pulmonary and Respiratory Medicine