Finite-element analysis of hepatic cryoablation around a large blood vessel

Cheolkyun Kim; Ann P. O'Rourke; James A. Will; David M. Mahvi; John G. Webster

doi:10.1109/TBME.2008.919837

Finite-element analysis of hepatic cryoablation around a large blood vessel

Cheolkyun Kim, Ann P. O'Rourke, James A. Will, David M. Mahvi, John G. Webster

Surgery, Surgical Oncology Division

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Cryoablation is a minimally invasive ablation technique for primary and metastatic hepatic tumors. Inadequate freezing around large blood vessels due to the warm blood flow can lead to local recurrence, and thus, necessitates close application of a cryoprobe to the large blood vessels. In this study, we constructed a perfusion model with an ex vivo bovine liver and ablated the tissue around a large blood vessel with one or two cryoprobes applied to the side of the vessel. The finite-element computer model developed in our previous study was modified to include a blood vessel and its convective heat transfer to the vicinity of the blood vessel. We compared the predicted simulation results to those acquired from this ex vivo perfusion model. The results indicate that blood vessels act as a heat source and generate steep temperature profiles in the area next to the large blood vessel. After validation, the maximum allowable distance between the cryoprobe and the large blood vessel for successful cryoablation was presented. The results of this study should be considered when placing cryoprobes in the vicinity of large blood vessels.

Original language	English (US)
Article number	20
Pages (from-to)	2087-2093
Number of pages	7
Journal	IEEE Transactions on Biomedical Engineering
Volume	55
Issue number	8
DOIs	https://doi.org/10.1109/TBME.2008.919837
State	Published - Aug 2008

Funding

Manuscript received June 15, 2007; revised January 8, 2008. This work was supported by the National Institute of Health (NIH) under Grant DK58839. Asterisk indicates corresponding author. C. Kim is with the Department of Biomedical Engineering, University of Wisconsin, Madison, WI 53706 USA (e-mail: [email protected]). A. P. O’Rourke and D. M. Mahvi are with the Department of Surgery, University of Wisconsin, Madison, WI 53792 USA (e-mail: ap.orourke@ hosp.wisc.edu; [email protected]). J. A. Will is with the Departments of Pathobiology, SVM and Animal Sciences, College of Agricultural and Life Sciences (CALS), University of Wisconsin, Madison, WI 53706 USA (e-mail: [email protected]). ∗J. G. Webster is with the Department of Biomedical Engineering, University of Wisconsin, Madison, WI 53706 USA (e-mail: [email protected]). Digital Object Identifier 10.1109/TBME.2008.919837

Keywords

Ablation
Blood perfusion
Blood vessel
Cryoablation
Cryosurgery
Ex vivo
Finite-element (FE) modeling
In vivo
Liver ablation

ASJC Scopus subject areas

Biomedical Engineering

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10.1109/TBME.2008.919837

Cite this

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title = "Finite-element analysis of hepatic cryoablation around a large blood vessel",

abstract = "Cryoablation is a minimally invasive ablation technique for primary and metastatic hepatic tumors. Inadequate freezing around large blood vessels due to the warm blood flow can lead to local recurrence, and thus, necessitates close application of a cryoprobe to the large blood vessels. In this study, we constructed a perfusion model with an ex vivo bovine liver and ablated the tissue around a large blood vessel with one or two cryoprobes applied to the side of the vessel. The finite-element computer model developed in our previous study was modified to include a blood vessel and its convective heat transfer to the vicinity of the blood vessel. We compared the predicted simulation results to those acquired from this ex vivo perfusion model. The results indicate that blood vessels act as a heat source and generate steep temperature profiles in the area next to the large blood vessel. After validation, the maximum allowable distance between the cryoprobe and the large blood vessel for successful cryoablation was presented. The results of this study should be considered when placing cryoprobes in the vicinity of large blood vessels.",

keywords = "Ablation, Blood perfusion, Blood vessel, Cryoablation, Cryosurgery, Ex vivo, Finite-element (FE) modeling, In vivo, Liver ablation",

author = "Cheolkyun Kim and O'Rourke, \{Ann P.\} and Will, \{James A.\} and Mahvi, \{David M.\} and Webster, \{John G.\}",

note = "Funding Information: Manuscript received June 15, 2007; revised January 8, 2008. This work was supported by the National Institute of Health (NIH) under Grant DK58839. Asterisk indicates corresponding author. C. Kim is with the Department of Biomedical Engineering, University of Wisconsin, Madison, WI 53706 USA (e-mail: [email protected]). A. P. O{\textquoteright}Rourke and D. M. Mahvi are with the Department of Surgery, University of Wisconsin, Madison, WI 53792 USA (e-mail: ap.orourke@ hosp.wisc.edu; [email protected]). J. A. Will is with the Departments of Pathobiology, SVM and Animal Sciences, College of Agricultural and Life Sciences (CALS), University of Wisconsin, Madison, WI 53706 USA (e-mail: [email protected]). ∗J. G. Webster is with the Department of Biomedical Engineering, University of Wisconsin, Madison, WI 53706 USA (e-mail: [email protected]). Digital Object Identifier 10.1109/TBME.2008.919837",

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AU - Mahvi, David M.

AU - Webster, John G.

N1 - Funding Information: Manuscript received June 15, 2007; revised January 8, 2008. This work was supported by the National Institute of Health (NIH) under Grant DK58839. Asterisk indicates corresponding author. C. Kim is with the Department of Biomedical Engineering, University of Wisconsin, Madison, WI 53706 USA (e-mail: [email protected]). A. P. O’Rourke and D. M. Mahvi are with the Department of Surgery, University of Wisconsin, Madison, WI 53792 USA (e-mail: ap.orourke@ hosp.wisc.edu; [email protected]). J. A. Will is with the Departments of Pathobiology, SVM and Animal Sciences, College of Agricultural and Life Sciences (CALS), University of Wisconsin, Madison, WI 53706 USA (e-mail: [email protected]). ∗J. G. Webster is with the Department of Biomedical Engineering, University of Wisconsin, Madison, WI 53706 USA (e-mail: [email protected]). Digital Object Identifier 10.1109/TBME.2008.919837

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N2 - Cryoablation is a minimally invasive ablation technique for primary and metastatic hepatic tumors. Inadequate freezing around large blood vessels due to the warm blood flow can lead to local recurrence, and thus, necessitates close application of a cryoprobe to the large blood vessels. In this study, we constructed a perfusion model with an ex vivo bovine liver and ablated the tissue around a large blood vessel with one or two cryoprobes applied to the side of the vessel. The finite-element computer model developed in our previous study was modified to include a blood vessel and its convective heat transfer to the vicinity of the blood vessel. We compared the predicted simulation results to those acquired from this ex vivo perfusion model. The results indicate that blood vessels act as a heat source and generate steep temperature profiles in the area next to the large blood vessel. After validation, the maximum allowable distance between the cryoprobe and the large blood vessel for successful cryoablation was presented. The results of this study should be considered when placing cryoprobes in the vicinity of large blood vessels.

AB - Cryoablation is a minimally invasive ablation technique for primary and metastatic hepatic tumors. Inadequate freezing around large blood vessels due to the warm blood flow can lead to local recurrence, and thus, necessitates close application of a cryoprobe to the large blood vessels. In this study, we constructed a perfusion model with an ex vivo bovine liver and ablated the tissue around a large blood vessel with one or two cryoprobes applied to the side of the vessel. The finite-element computer model developed in our previous study was modified to include a blood vessel and its convective heat transfer to the vicinity of the blood vessel. We compared the predicted simulation results to those acquired from this ex vivo perfusion model. The results indicate that blood vessels act as a heat source and generate steep temperature profiles in the area next to the large blood vessel. After validation, the maximum allowable distance between the cryoprobe and the large blood vessel for successful cryoablation was presented. The results of this study should be considered when placing cryoprobes in the vicinity of large blood vessels.

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KW - Liver ablation

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Finite-element analysis of hepatic cryoablation around a large blood vessel

Abstract

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