Finite element modeling of atherosclerotic plaque

A. I. Veress; J. F. Cornhill; K. A. Powell; E. E. Herderick; J. D. Thomas

Finite element modeling of atherosclerotic plaque

A. I. Veress^*, J. F. Cornhill, K. A. Powell, E. E. Herderick, J. D. Thomas

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

2-D mathematical models of the coronary walls have been developed based on actual plaque morphology from a multi-center study of coronary disease (Pathological Determinants of Atherosclerosis in Youths, PDAY). METHODS: The probability of lipid maps were used to define a typical lesion's physical dimensions for four age ranges. Under physiological loading from intra-arterial pressure, the resulting intramural stress distributions were quantified as a function of patient age. RESULTS: The area of highest stress in the 15-19 year group was shifted from the healthy wall opposite the lesion to the area where the normal intima is adjacent to the plaque cap and increased with age. CONCLUSION: The age related development of atherosclerosis leads to a predictable increase in localized wall stress, which may predispose a plaque to rupture.

Original language	English (US)
Title of host publication	Computers in Cardiology
Publisher	Publ by IEEE
Pages	791-794
Number of pages	4
ISBN (Print)	0818654708
State	Published - Dec 1 1993
Event	Proceedings of the 1993 Conference on Computers in Cardiology - London, UK Duration: Sep 5 1993 → Sep 8 1993

Other

Other	Proceedings of the 1993 Conference on Computers in Cardiology
City	London, UK
Period	9/5/93 → 9/8/93

ASJC Scopus subject areas

Software
Cardiology and Cardiovascular Medicine

Cite this

@inproceedings{7342629858894312b14a8cd6bfd0e7df,

title = "Finite element modeling of atherosclerotic plaque",

abstract = "2-D mathematical models of the coronary walls have been developed based on actual plaque morphology from a multi-center study of coronary disease (Pathological Determinants of Atherosclerosis in Youths, PDAY). METHODS: The probability of lipid maps were used to define a typical lesion's physical dimensions for four age ranges. Under physiological loading from intra-arterial pressure, the resulting intramural stress distributions were quantified as a function of patient age. RESULTS: The area of highest stress in the 15-19 year group was shifted from the healthy wall opposite the lesion to the area where the normal intima is adjacent to the plaque cap and increased with age. CONCLUSION: The age related development of atherosclerosis leads to a predictable increase in localized wall stress, which may predispose a plaque to rupture.",

author = "Veress, {A. I.} and Cornhill, {J. F.} and Powell, {K. A.} and Herderick, {E. E.} and Thomas, {J. D.}",

year = "1993",

month = dec,

day = "1",

language = "English (US)",

isbn = "0818654708",

pages = "791--794",

booktitle = "Computers in Cardiology",

publisher = "Publ by IEEE",

note = "Proceedings of the 1993 Conference on Computers in Cardiology ; Conference date: 05-09-1993 Through 08-09-1993",

}

TY - GEN

T1 - Finite element modeling of atherosclerotic plaque

AU - Veress, A. I.

AU - Cornhill, J. F.

AU - Powell, K. A.

AU - Herderick, E. E.

AU - Thomas, J. D.

PY - 1993/12/1

Y1 - 1993/12/1

N2 - 2-D mathematical models of the coronary walls have been developed based on actual plaque morphology from a multi-center study of coronary disease (Pathological Determinants of Atherosclerosis in Youths, PDAY). METHODS: The probability of lipid maps were used to define a typical lesion's physical dimensions for four age ranges. Under physiological loading from intra-arterial pressure, the resulting intramural stress distributions were quantified as a function of patient age. RESULTS: The area of highest stress in the 15-19 year group was shifted from the healthy wall opposite the lesion to the area where the normal intima is adjacent to the plaque cap and increased with age. CONCLUSION: The age related development of atherosclerosis leads to a predictable increase in localized wall stress, which may predispose a plaque to rupture.

AB - 2-D mathematical models of the coronary walls have been developed based on actual plaque morphology from a multi-center study of coronary disease (Pathological Determinants of Atherosclerosis in Youths, PDAY). METHODS: The probability of lipid maps were used to define a typical lesion's physical dimensions for four age ranges. Under physiological loading from intra-arterial pressure, the resulting intramural stress distributions were quantified as a function of patient age. RESULTS: The area of highest stress in the 15-19 year group was shifted from the healthy wall opposite the lesion to the area where the normal intima is adjacent to the plaque cap and increased with age. CONCLUSION: The age related development of atherosclerosis leads to a predictable increase in localized wall stress, which may predispose a plaque to rupture.

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M3 - Conference contribution

AN - SCOPUS:0027809113

SN - 0818654708

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EP - 794

BT - Computers in Cardiology

PB - Publ by IEEE

T2 - Proceedings of the 1993 Conference on Computers in Cardiology

Y2 - 5 September 1993 through 8 September 1993

ER -

Finite element modeling of atherosclerotic plaque

Abstract

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ASJC Scopus subject areas

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