Finite element modeling of atherosclerotic plaque

A. I. Veress*, J. F. Cornhill, K. A. Powell, E. E. Herderick, J. D. Thomas

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

2-D mathematical models of the coronary walls have been developed based on actual plaque morphology from a multi-center study of coronary disease (Pathological Determinants of Atherosclerosis in Youths, PDAY). METHODS: The probability of lipid maps were used to define a typical lesion's physical dimensions for four age ranges. Under physiological loading from intra-arterial pressure, the resulting intramural stress distributions were quantified as a function of patient age. RESULTS: The area of highest stress in the 15-19 year group was shifted from the healthy wall opposite the lesion to the area where the normal intima is adjacent to the plaque cap and increased with age. CONCLUSION: The age related development of atherosclerosis leads to a predictable increase in localized wall stress, which may predispose a plaque to rupture.

Original languageEnglish (US)
Title of host publicationComputers in Cardiology
PublisherPubl by IEEE
Pages791-794
Number of pages4
ISBN (Print)0818654708
StatePublished - Dec 1 1993
EventProceedings of the 1993 Conference on Computers in Cardiology - London, UK
Duration: Sep 5 1993Sep 8 1993

Other

OtherProceedings of the 1993 Conference on Computers in Cardiology
CityLondon, UK
Period9/5/939/8/93

ASJC Scopus subject areas

  • Software
  • Cardiology and Cardiovascular Medicine

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    Veress, A. I., Cornhill, J. F., Powell, K. A., Herderick, E. E., & Thomas, J. D. (1993). Finite element modeling of atherosclerotic plaque. In Computers in Cardiology (pp. 791-794). Publ by IEEE.