2D finite element models were used to determined how lesion stress is affected by finite element model assumptions and deviations in plaque geometry and material properties from mean values. The 20%, 30% and 40% stenosis geometries were based histological analysis of 625 coronary plaques studied in the Pathobiological Development of Atherosclerosis in Youth study. Significant error in finite element prediction scan occur if a large strain analysis and nonlinear material properties are not used. For each stenosis value, the mid-cap stress and shoulder stress are most sensitive to 10% change in a geometric feature, either cap thickness or lipid volume, rather a 10% change in cap or lipid stiffness. The largest sensitivity to most parameters occurs at 30% stenosis.
|Original language||English (US)|
|Journal||Annals of Biomedical Engineering|
|Issue number||SUPPL. 1|
|State||Published - Dec 1 2000|
ASJC Scopus subject areas
- Biomedical Engineering