First spike latency and spike count as functions of tone amplitude and frequency in the inferior colliculus of mice

Xiaodong Tan; Xiao Wang; Weiguo Yang; Zhongju Xiao

doi:10.1016/j.heares.2007.10.002

First spike latency and spike count as functions of tone amplitude and frequency in the inferior colliculus of mice

Xiaodong Tan, Xiao Wang, Weiguo Yang, Zhongju Xiao^*

^*Corresponding author for this work

Otolaryngology

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Spike counts (SC) or, spike rate and first spike latency (FSL), are both used to evaluate the responses of neurons to amplitudes and frequencies of acoustic stimuli. However, it is unclear which one is more suitable as a parameter for evaluating the responses of neurons to acoustic amplitudes and frequencies, since systematic comparisons between SC and FSL tuned to different amplitudes and frequencies, are scarce. This study systematically compared the precision and stability (i.e., the resolution and the coefficient variation, CV) of SC- and FSL-function as frequencies and amplitudes in the inferior colliculus of mice. The results showed that: (1) the SC-amplitude functions were of diverse shape (monotonic, nonmonotonic and saturated) whereas the FSL-amplitude functions were in close registration, in which FSL decreased with the increase of amplitude and no paradoxical (an increase in FSL with increasing amplitude) or constant (an independence of FSL on amplitude) neuron was observed; (2) the discriminability (resolution) of differences in amplitude and frequency based on FSL are higher than those based on SC; (3) the CVs of FSL for low amplitude stimuli were smaller than those of SC; (4) the fraction of neurons for which BF = CF (within ±500 Hz) obtained from FSL was higher than that from SC at any amplitude of sound. Therefore, SC and FSL may vary, independent from each other and represent different parameters of an acoustic stimulus, but FSL with its precision and stability appears to be a better parameter than SC in evaluation of the response of a neuron to frequency and amplitude in mouse inferior colliculus.

Original language	English (US)
Pages (from-to)	90-104
Number of pages	15
Journal	Hearing research
Volume	235
Issue number	1-2
DOIs	https://doi.org/10.1016/j.heares.2007.10.002
State	Published - Jan 2008

Funding

This work was supported by grants from the National Natural Science Foundation of China (Nos. 30570571 and 30670665). We are grateful to Drs. Q. John Fu (Saint Louis University School of Public) and P.Y. Chen (Statistics Department in our University) for help with statistic processing; to two anonymous reviewers for their comments on a previous version of the manuscript; and to the editor.

Keywords

Auditory system
Neuron
Spike rate

ASJC Scopus subject areas

Sensory Systems

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10.1016/j.heares.2007.10.002

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title = "First spike latency and spike count as functions of tone amplitude and frequency in the inferior colliculus of mice",

abstract = "Spike counts (SC) or, spike rate and first spike latency (FSL), are both used to evaluate the responses of neurons to amplitudes and frequencies of acoustic stimuli. However, it is unclear which one is more suitable as a parameter for evaluating the responses of neurons to acoustic amplitudes and frequencies, since systematic comparisons between SC and FSL tuned to different amplitudes and frequencies, are scarce. This study systematically compared the precision and stability (i.e., the resolution and the coefficient variation, CV) of SC- and FSL-function as frequencies and amplitudes in the inferior colliculus of mice. The results showed that: (1) the SC-amplitude functions were of diverse shape (monotonic, nonmonotonic and saturated) whereas the FSL-amplitude functions were in close registration, in which FSL decreased with the increase of amplitude and no paradoxical (an increase in FSL with increasing amplitude) or constant (an independence of FSL on amplitude) neuron was observed; (2) the discriminability (resolution) of differences in amplitude and frequency based on FSL are higher than those based on SC; (3) the CVs of FSL for low amplitude stimuli were smaller than those of SC; (4) the fraction of neurons for which BF = CF (within ±500 Hz) obtained from FSL was higher than that from SC at any amplitude of sound. Therefore, SC and FSL may vary, independent from each other and represent different parameters of an acoustic stimulus, but FSL with its precision and stability appears to be a better parameter than SC in evaluation of the response of a neuron to frequency and amplitude in mouse inferior colliculus.",

keywords = "Auditory system, Neuron, Spike rate",

author = "Xiaodong Tan and Xiao Wang and Weiguo Yang and Zhongju Xiao",

note = "Funding Information: This work was supported by grants from the National Natural Science Foundation of China (Nos. 30570571 and 30670665). We are grateful to Drs. Q. John Fu (Saint Louis University School of Public) and P.Y. Chen (Statistics Department in our University) for help with statistic processing; to two anonymous reviewers for their comments on a previous version of the manuscript; and to the editor.",

year = "2008",

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doi = "10.1016/j.heares.2007.10.002",

language = "English (US)",

volume = "235",

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T1 - First spike latency and spike count as functions of tone amplitude and frequency in the inferior colliculus of mice

AU - Tan, Xiaodong

AU - Wang, Xiao

AU - Yang, Weiguo

AU - Xiao, Zhongju

N1 - Funding Information: This work was supported by grants from the National Natural Science Foundation of China (Nos. 30570571 and 30670665). We are grateful to Drs. Q. John Fu (Saint Louis University School of Public) and P.Y. Chen (Statistics Department in our University) for help with statistic processing; to two anonymous reviewers for their comments on a previous version of the manuscript; and to the editor.

PY - 2008/1

Y1 - 2008/1

N2 - Spike counts (SC) or, spike rate and first spike latency (FSL), are both used to evaluate the responses of neurons to amplitudes and frequencies of acoustic stimuli. However, it is unclear which one is more suitable as a parameter for evaluating the responses of neurons to acoustic amplitudes and frequencies, since systematic comparisons between SC and FSL tuned to different amplitudes and frequencies, are scarce. This study systematically compared the precision and stability (i.e., the resolution and the coefficient variation, CV) of SC- and FSL-function as frequencies and amplitudes in the inferior colliculus of mice. The results showed that: (1) the SC-amplitude functions were of diverse shape (monotonic, nonmonotonic and saturated) whereas the FSL-amplitude functions were in close registration, in which FSL decreased with the increase of amplitude and no paradoxical (an increase in FSL with increasing amplitude) or constant (an independence of FSL on amplitude) neuron was observed; (2) the discriminability (resolution) of differences in amplitude and frequency based on FSL are higher than those based on SC; (3) the CVs of FSL for low amplitude stimuli were smaller than those of SC; (4) the fraction of neurons for which BF = CF (within ±500 Hz) obtained from FSL was higher than that from SC at any amplitude of sound. Therefore, SC and FSL may vary, independent from each other and represent different parameters of an acoustic stimulus, but FSL with its precision and stability appears to be a better parameter than SC in evaluation of the response of a neuron to frequency and amplitude in mouse inferior colliculus.

AB - Spike counts (SC) or, spike rate and first spike latency (FSL), are both used to evaluate the responses of neurons to amplitudes and frequencies of acoustic stimuli. However, it is unclear which one is more suitable as a parameter for evaluating the responses of neurons to acoustic amplitudes and frequencies, since systematic comparisons between SC and FSL tuned to different amplitudes and frequencies, are scarce. This study systematically compared the precision and stability (i.e., the resolution and the coefficient variation, CV) of SC- and FSL-function as frequencies and amplitudes in the inferior colliculus of mice. The results showed that: (1) the SC-amplitude functions were of diverse shape (monotonic, nonmonotonic and saturated) whereas the FSL-amplitude functions were in close registration, in which FSL decreased with the increase of amplitude and no paradoxical (an increase in FSL with increasing amplitude) or constant (an independence of FSL on amplitude) neuron was observed; (2) the discriminability (resolution) of differences in amplitude and frequency based on FSL are higher than those based on SC; (3) the CVs of FSL for low amplitude stimuli were smaller than those of SC; (4) the fraction of neurons for which BF = CF (within ±500 Hz) obtained from FSL was higher than that from SC at any amplitude of sound. Therefore, SC and FSL may vary, independent from each other and represent different parameters of an acoustic stimulus, but FSL with its precision and stability appears to be a better parameter than SC in evaluation of the response of a neuron to frequency and amplitude in mouse inferior colliculus.

KW - Auditory system

KW - Neuron

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VL - 235

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JO - Hearing research

JF - Hearing research

IS - 1-2

ER -

First spike latency and spike count as functions of tone amplitude and frequency in the inferior colliculus of mice

Abstract

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Keywords

ASJC Scopus subject areas

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