First Trimester Placental Growth Factor and Soluble Fms-Like Tyrosine Kinase 1 and Risk for Preeclampsia

Ravi Thadhani*, Walter P. Mutter, Myles Wolf, Richard J. Levine, Robert N. Taylor, Vikas P. Sukhatme, Jeffrey Ecker, S. Ananth Karumanchi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

286 Scopus citations


An imbalance of pro- and antiangiogenic factors may lead to preeclampsia (PE). In this prospective nested case-control study, we investigated whether first trimester serum levels of placental growth factor (PlGF), a potent angiogenic factor, and its soluble inhibitor, soluble fms-like tyrosine kinase 1 (sFlt1), distinguished women who developed PE (n = 40) from those who developed gestational hypertension (n = 40), delivered a small for gestational age (SGA) newborn (n = 40), or completed a full term normal pregnancy (n = 80). Compared with controls, serum PlGF levels were lower among women who developed PE (23 ± 24 pg/ml vs. 63 ± 145 pg/ml; P < 0.01) or gestational hypertension (27 ± 19 pg/ml; P = 0.03), or who delivered a SGA newborn (21 ± 16 pg/ml; P < 0.01). In contrast, serum sFlt1 levels did not markedly differ between the groups: PE, 1048 ± 657 pg/ml; gestational hypertension, 942 ± 437 pg/ml; SGA newborns, 1011 ± 479 pg/ml; and normal controls, 973 ± 490 pg/ml. Multivariable analysis adjusting for potential confounders and serum sFlt1 levels demonstrated a 3.7-fold (95% confidence interval, 1.2-12.5) increase in risk for PE for every log unit decrease in serum levels of PlGF compared with controls. Analyses for gestational hypertension and SGA were not significant. Examined in tertiles, the risk for PE was increased 28.7-fold (95% confidence interval, 2.3-351.0) in the third (<12 pg/ml) compared with the first (>39 pg/ml) PlGF tertile. First trimester serum levels of PlGF and sFlt1 may identify women at high risk for PE.

Original languageEnglish (US)
Pages (from-to)770-775
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Issue number2
StatePublished - Feb 2004
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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