First two patients with ulcerative colitis who developed classical thrombotic thrombocytopenic purpura successfully treated with medical therapy and plasma exchange

Beverly W. Baron*, Hye Ran Jeon, Catherine Glunz, Amy Peterson, Russell Cohen, Stephen Hanauer, David Rubin, John Hart, Joseph M. Baron

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The association of ulcerative colitis (UC) and thrombotic thrombocytopenic purpura (TTP) is rare. Only one prior patient with these two syndromes has been reported in the literature. In that case, splenectomy and proctectomy were performed to control the symptoms of TTP. We present two patients with UC who developed TTP and were successfully treated with multiple plasma exchanges (PEXs) in conjunction with medical therapy without the necessity for surgical intervention. Acquired TTP may be another extraintestinal autoimmune feature of UC. TTP in association with UC may be refractory to high-dose steroids and PEX, possibly requiring vincristine and splenectomy, as in the one previously reported case, to achieve remission.

Original languageEnglish (US)
Pages (from-to)204-206
Number of pages3
JournalJournal of Clinical Apheresis
Volume17
Issue number4
DOIs
StatePublished - Dec 1 2002

Keywords

  • Plasma exchange
  • Thrombotic thrombocytopenic purpura
  • Ulcerative colitis

ASJC Scopus subject areas

  • Hematology

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