Fish consumption, erythrocyte fatty acids, and preterm birth

Mark A. Klebanoff, Margaret Harper, Yinglei Lai, John Thorp, Yoram Sorokin, Michael W. Varner, Ronald J. Wapner, Steve N. Caritis, Jay D. Iams, Marshall W. Carpenter, Alan M. Peaceman, Brian M. Mercer, Anthony Sciscione, Dwight J. Rouse, Susan M. Ramin, Garland D. Anderson

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective: To estimate the association between fish consumption and erythrocyte omega-3 long-chain polyunsaturated fatty acids and preterm birth in a high-risk cohort. Methods:This was an ancillary study to a randomized trial of omega-3 supplementation to prevent preterm birth in women with at least one previous spontaneous preterm delivery. Dietary fish intake was assessed by questionnaire and erythrocyte fatty acids were measured at enrollment (16-21 completed weeks of gestation). The association between fish consumption and preterm delivery was modeled with linear and quadratic terms. Rssults: The probability of preterm birth was 48.6% among women eating fish less than once a month and 35.9% among women eating fish more often (P<.001). The adjusted odds ratio for preterm birth among women reporting moderately frequent fish consumption (three servings per week) was 0.60 (95% confidence interval 0.38-0.95), with no further reduction in preterm birth among women who consumed more than three servings of fish per week. Erythrocyte omega-3 levels correlated weakly but significantly with frequency of fish intake (Spearman r=0.22, P<.001); women in the lowest quartile of erythrocyte omega-3 levels were more likely to report consuming less than one fish meal per month (40.3%) than were women in the highest three quartiles (26.3%, P<.001). CONCLUSION:: Moderate fish intake (up to three meals per week) before 22 weeks of gestation was associated with a reduction in repeat preterm birth. More than moderate consumption did not confer additional benefit. These results support the recommendations of the U.S. Food and Drug Administration and the American Congress of Obstetricians and Gynecologists for fish consumption during pregnancy.

Original languageEnglish (US)
Pages (from-to)1071-1077
Number of pages7
JournalObstetrics and Gynecology
Volume117
Issue number5
DOIs
StatePublished - Jan 1 2011

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Premature Birth
Fishes
Fatty Acids
Erythrocytes
Pregnancy
Meals
Eating
United States Food and Drug Administration
Unsaturated Fatty Acids
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Klebanoff, M. A., Harper, M., Lai, Y., Thorp, J., Sorokin, Y., Varner, M. W., ... Anderson, G. D. (2011). Fish consumption, erythrocyte fatty acids, and preterm birth. Obstetrics and Gynecology, 117(5), 1071-1077. https://doi.org/10.1097/AOG.0b013e31821645dc
Klebanoff, Mark A. ; Harper, Margaret ; Lai, Yinglei ; Thorp, John ; Sorokin, Yoram ; Varner, Michael W. ; Wapner, Ronald J. ; Caritis, Steve N. ; Iams, Jay D. ; Carpenter, Marshall W. ; Peaceman, Alan M. ; Mercer, Brian M. ; Sciscione, Anthony ; Rouse, Dwight J. ; Ramin, Susan M. ; Anderson, Garland D. / Fish consumption, erythrocyte fatty acids, and preterm birth. In: Obstetrics and Gynecology. 2011 ; Vol. 117, No. 5. pp. 1071-1077.
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abstract = "Objective: To estimate the association between fish consumption and erythrocyte omega-3 long-chain polyunsaturated fatty acids and preterm birth in a high-risk cohort. Methods:This was an ancillary study to a randomized trial of omega-3 supplementation to prevent preterm birth in women with at least one previous spontaneous preterm delivery. Dietary fish intake was assessed by questionnaire and erythrocyte fatty acids were measured at enrollment (16-21 completed weeks of gestation). The association between fish consumption and preterm delivery was modeled with linear and quadratic terms. Rssults: The probability of preterm birth was 48.6{\%} among women eating fish less than once a month and 35.9{\%} among women eating fish more often (P<.001). The adjusted odds ratio for preterm birth among women reporting moderately frequent fish consumption (three servings per week) was 0.60 (95{\%} confidence interval 0.38-0.95), with no further reduction in preterm birth among women who consumed more than three servings of fish per week. Erythrocyte omega-3 levels correlated weakly but significantly with frequency of fish intake (Spearman r=0.22, P<.001); women in the lowest quartile of erythrocyte omega-3 levels were more likely to report consuming less than one fish meal per month (40.3{\%}) than were women in the highest three quartiles (26.3{\%}, P<.001). CONCLUSION:: Moderate fish intake (up to three meals per week) before 22 weeks of gestation was associated with a reduction in repeat preterm birth. More than moderate consumption did not confer additional benefit. These results support the recommendations of the U.S. Food and Drug Administration and the American Congress of Obstetricians and Gynecologists for fish consumption during pregnancy.",
author = "Klebanoff, {Mark A.} and Margaret Harper and Yinglei Lai and John Thorp and Yoram Sorokin and Varner, {Michael W.} and Wapner, {Ronald J.} and Caritis, {Steve N.} and Iams, {Jay D.} and Carpenter, {Marshall W.} and Peaceman, {Alan M.} and Mercer, {Brian M.} and Anthony Sciscione and Rouse, {Dwight J.} and Ramin, {Susan M.} and Anderson, {Garland D.}",
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Klebanoff, MA, Harper, M, Lai, Y, Thorp, J, Sorokin, Y, Varner, MW, Wapner, RJ, Caritis, SN, Iams, JD, Carpenter, MW, Peaceman, AM, Mercer, BM, Sciscione, A, Rouse, DJ, Ramin, SM & Anderson, GD 2011, 'Fish consumption, erythrocyte fatty acids, and preterm birth', Obstetrics and Gynecology, vol. 117, no. 5, pp. 1071-1077. https://doi.org/10.1097/AOG.0b013e31821645dc

Fish consumption, erythrocyte fatty acids, and preterm birth. / Klebanoff, Mark A.; Harper, Margaret; Lai, Yinglei; Thorp, John; Sorokin, Yoram; Varner, Michael W.; Wapner, Ronald J.; Caritis, Steve N.; Iams, Jay D.; Carpenter, Marshall W.; Peaceman, Alan M.; Mercer, Brian M.; Sciscione, Anthony; Rouse, Dwight J.; Ramin, Susan M.; Anderson, Garland D.

In: Obstetrics and Gynecology, Vol. 117, No. 5, 01.01.2011, p. 1071-1077.

Research output: Contribution to journalArticle

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T1 - Fish consumption, erythrocyte fatty acids, and preterm birth

AU - Klebanoff, Mark A.

AU - Harper, Margaret

AU - Lai, Yinglei

AU - Thorp, John

AU - Sorokin, Yoram

AU - Varner, Michael W.

AU - Wapner, Ronald J.

AU - Caritis, Steve N.

AU - Iams, Jay D.

AU - Carpenter, Marshall W.

AU - Peaceman, Alan M.

AU - Mercer, Brian M.

AU - Sciscione, Anthony

AU - Rouse, Dwight J.

AU - Ramin, Susan M.

AU - Anderson, Garland D.

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Objective: To estimate the association between fish consumption and erythrocyte omega-3 long-chain polyunsaturated fatty acids and preterm birth in a high-risk cohort. Methods:This was an ancillary study to a randomized trial of omega-3 supplementation to prevent preterm birth in women with at least one previous spontaneous preterm delivery. Dietary fish intake was assessed by questionnaire and erythrocyte fatty acids were measured at enrollment (16-21 completed weeks of gestation). The association between fish consumption and preterm delivery was modeled with linear and quadratic terms. Rssults: The probability of preterm birth was 48.6% among women eating fish less than once a month and 35.9% among women eating fish more often (P<.001). The adjusted odds ratio for preterm birth among women reporting moderately frequent fish consumption (three servings per week) was 0.60 (95% confidence interval 0.38-0.95), with no further reduction in preterm birth among women who consumed more than three servings of fish per week. Erythrocyte omega-3 levels correlated weakly but significantly with frequency of fish intake (Spearman r=0.22, P<.001); women in the lowest quartile of erythrocyte omega-3 levels were more likely to report consuming less than one fish meal per month (40.3%) than were women in the highest three quartiles (26.3%, P<.001). CONCLUSION:: Moderate fish intake (up to three meals per week) before 22 weeks of gestation was associated with a reduction in repeat preterm birth. More than moderate consumption did not confer additional benefit. These results support the recommendations of the U.S. Food and Drug Administration and the American Congress of Obstetricians and Gynecologists for fish consumption during pregnancy.

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Klebanoff MA, Harper M, Lai Y, Thorp J, Sorokin Y, Varner MW et al. Fish consumption, erythrocyte fatty acids, and preterm birth. Obstetrics and Gynecology. 2011 Jan 1;117(5):1071-1077. https://doi.org/10.1097/AOG.0b013e31821645dc