Flexible and Transparent Metal Nanowire Microelectrode Arrays and Interconnects for Electrophysiology, Optogenetics, and Optical Mapping

Zhiyuan Chen, Nicolas Boyajian, Zexu Lin, Rose T. Yin, Sofian N. Obaid, Jinbi Tian, Jaclyn A. Brennan, Sheena W. Chen, Alana N. Miniovich, Leqi Lin, Yarong Qi, Xitong Liu, Igor R. Efimov*, Luyao Lu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Transparent microelectrodes have recently emerged as a promising approach for crosstalk-free multifunctional electrical and optical biointerfacing. High-performance flexible platforms that allow seamless integration with soft tissue systems for such applications are urgently needed. Here, silver nanowires (Ag NWs)-based transparent microelectrode arrays (MEAs) and interconnects are designed to meet this demand. The nanowire networks exhibit a high optical transparency >90.0% at 550 nm, and superior mechanical stability up to 100,000 bending cycles at 5 mm radius. The Ag NWs microelectrodes preserve low normalized electrochemical impedance of 3.4–15 Ω cm2 at 1 kHz, and the interconnects demonstrate excellent sheet resistance (Rsh) of 4.1–25 Ω sq−1. In vivo histological analysis reveals that the Ag NWs structures are biocompatible. Studies on Langendorff-perfused mouse and rat hearts demonstrate that the Ag NWs MEAs enable high-fidelity real-time monitoring of heart rhythm during co-localized optogenetic pacing and optical mapping. This proof-of-concept work illustrates that the solution-processed, transparent, and flexible Ag NWs structures are a promising candidate for the next-generation of large-area multifunctional biointerfaces for interrogating complex biological systems in basic and translational research.

Original languageEnglish (US)
Article number2100225
JournalAdvanced Materials Technologies
Volume6
Issue number7
DOIs
StatePublished - Jul 2021
Externally publishedYes

Keywords

  • bioelectronics
  • electrophysiology
  • metal nanowires
  • optical mapping
  • optogenetics
  • transparent microelectrodes

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Industrial and Manufacturing Engineering

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