Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo

Jonathan Viventi; Dae Hyeong Kim; Leif Vigeland; Eric S. Frechette; Justin A. Blanco; Yun Soung Kim; Andrew E. Avrin; Vineet R. Tiruvadi; Suk Won Hwang; Ann C. Vanleer; Drausin F. Wulsin; Kathryn Davis; Casey E. Gelber; Larry Palmer; Jan Van Der Spiegel; Jian Wu; Jianliang Xiao; Yonggang Huang; Diego Contreras; John A. Rogers; Brian Litt

doi:10.1038/nn.2973

Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo

Jonathan Viventi, Dae Hyeong Kim, Leif Vigeland, Eric S. Frechette, Justin A. Blanco, Yun Soung Kim, Andrew E. Avrin, Vineet R. Tiruvadi, Suk Won Hwang, Ann C. Vanleer, Drausin F. Wulsin, Kathryn Davis, Casey E. Gelber, Larry Palmer, Jan Van Der Spiegel, Jian Wu, Jianliang Xiao, Yonggang Huang, Diego Contreras, John A. RogersBrian Litt^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

917 Scopus citations

Abstract

Arrays of electrodes for recording and stimulating the brain are used throughout clinical medicine and basic neuroscience research, yet are unable to sample large areas of the brain while maintaining high spatial resolution because of the need to individually wire each passive sensor at the electrode-tissue interface. To overcome this constraint, we developed new devices that integrate ultrathin and flexible silicon nanomembrane transistors into the electrode array, enabling new dense arrays of thousands of amplified and multiplexed sensors that are connected using fewer wires. We used this system to record spatial properties of cat brain activity in vivo, including sleep spindles, single-trial visual evoked responses and electrographic seizures. We found that seizures may manifest as recurrent spiral waves that propagate in the neocortex. The developments reported here herald a new generation of diagnostic and therapeutic brain-machine interface devices.

Original language	English (US)
Pages (from-to)	1599-1605
Number of pages	7
Journal	Nature neuroscience
Volume	14
Issue number	12
DOIs	https://doi.org/10.1038/nn.2973
State	Published - Dec 2011

Funding

This work was supported by the National Science Foundation (grant DMI-0328162) and the US Department of Energy, Division of Materials Sciences (Award No. DE-FG02-07ER46471), through the Materials Research Laboratory and Center for Microanalysis of Materials (DE-FG02-07ER46453) at the University of Illinois at Urbana-Champaign. J.A.R. acknowledges a National Security Science and Engineering Faculty Fellowship. Work at the University of Pennsylvania was supported by grants from the US National Institutes of Health (National Institute of Neurological Disorders and Stroke RO1-NS041811 and RO1-NS48598), the Julie’s Hope Award from the Citizens United for Research in Epilepsy, and the Dr. Michel and Mrs. Anna Mirowski Discovery Fund for Epilepsy Research. J.V. received a Ruth L. Kirschstein National Research Service Award (2T32HL007954) from the US National Institutes of Health, National Heart, Lung and Blood Institute.

ASJC Scopus subject areas

General Neuroscience

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10.1038/nn.2973

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Viventi, J., Kim, D. H., Vigeland, L., Frechette, E. S., Blanco, J. A., Kim, Y. S., Avrin, A. E., Tiruvadi, V. R., Hwang, S. W., Vanleer, A. C., Wulsin, D. F., Davis, K., Gelber, C. E., Palmer, L., Van Der Spiegel, J., Wu, J., Xiao, J., Huang, Y., Contreras, D., ... Litt, B. (2011). Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo. Nature neuroscience, 14(12), 1599-1605. https://doi.org/10.1038/nn.2973

@article{6bb3fe25099847a2a677d52787130356,

title = "Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo",

abstract = "Arrays of electrodes for recording and stimulating the brain are used throughout clinical medicine and basic neuroscience research, yet are unable to sample large areas of the brain while maintaining high spatial resolution because of the need to individually wire each passive sensor at the electrode-tissue interface. To overcome this constraint, we developed new devices that integrate ultrathin and flexible silicon nanomembrane transistors into the electrode array, enabling new dense arrays of thousands of amplified and multiplexed sensors that are connected using fewer wires. We used this system to record spatial properties of cat brain activity in vivo, including sleep spindles, single-trial visual evoked responses and electrographic seizures. We found that seizures may manifest as recurrent spiral waves that propagate in the neocortex. The developments reported here herald a new generation of diagnostic and therapeutic brain-machine interface devices.",

author = "Jonathan Viventi and Kim, {Dae Hyeong} and Leif Vigeland and Frechette, {Eric S.} and Blanco, {Justin A.} and Kim, {Yun Soung} and Avrin, {Andrew E.} and Tiruvadi, {Vineet R.} and Hwang, {Suk Won} and Vanleer, {Ann C.} and Wulsin, {Drausin F.} and Kathryn Davis and Gelber, {Casey E.} and Larry Palmer and {Van Der Spiegel}, Jan and Jian Wu and Jianliang Xiao and Yonggang Huang and Diego Contreras and Rogers, {John A.} and Brian Litt",

note = "Funding Information: This work was supported by the National Science Foundation (grant DMI-0328162) and the US Department of Energy, Division of Materials Sciences (Award No. DE-FG02-07ER46471), through the Materials Research Laboratory and Center for Microanalysis of Materials (DE-FG02-07ER46453) at the University of Illinois at Urbana-Champaign. J.A.R. acknowledges a National Security Science and Engineering Faculty Fellowship. Work at the University of Pennsylvania was supported by grants from the US National Institutes of Health (National Institute of Neurological Disorders and Stroke RO1-NS041811 and RO1-NS48598), the Julie{\textquoteright}s Hope Award from the Citizens United for Research in Epilepsy, and the Dr. Michel and Mrs. Anna Mirowski Discovery Fund for Epilepsy Research. J.V. received a Ruth L. Kirschstein National Research Service Award (2T32HL007954) from the US National Institutes of Health, National Heart, Lung and Blood Institute.",

year = "2011",

month = dec,

doi = "10.1038/nn.2973",

language = "English (US)",

volume = "14",

pages = "1599--1605",

journal = "Nature neuroscience",

issn = "1097-6256",

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number = "12",

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Viventi, J, Kim, DH, Vigeland, L, Frechette, ES, Blanco, JA, Kim, YS, Avrin, AE, Tiruvadi, VR, Hwang, SW, Vanleer, AC, Wulsin, DF, Davis, K, Gelber, CE, Palmer, L, Van Der Spiegel, J, Wu, J, Xiao, J, Huang, Y, Contreras, D, Rogers, JA & Litt, B 2011, 'Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo', Nature neuroscience, vol. 14, no. 12, pp. 1599-1605. https://doi.org/10.1038/nn.2973

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T1 - Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo

AU - Viventi, Jonathan

AU - Kim, Dae Hyeong

AU - Vigeland, Leif

AU - Frechette, Eric S.

AU - Blanco, Justin A.

AU - Kim, Yun Soung

AU - Avrin, Andrew E.

AU - Tiruvadi, Vineet R.

AU - Hwang, Suk Won

AU - Vanleer, Ann C.

AU - Wulsin, Drausin F.

AU - Davis, Kathryn

AU - Gelber, Casey E.

AU - Palmer, Larry

AU - Van Der Spiegel, Jan

AU - Wu, Jian

AU - Xiao, Jianliang

AU - Huang, Yonggang

AU - Contreras, Diego

AU - Rogers, John A.

AU - Litt, Brian

N1 - Funding Information: This work was supported by the National Science Foundation (grant DMI-0328162) and the US Department of Energy, Division of Materials Sciences (Award No. DE-FG02-07ER46471), through the Materials Research Laboratory and Center for Microanalysis of Materials (DE-FG02-07ER46453) at the University of Illinois at Urbana-Champaign. J.A.R. acknowledges a National Security Science and Engineering Faculty Fellowship. Work at the University of Pennsylvania was supported by grants from the US National Institutes of Health (National Institute of Neurological Disorders and Stroke RO1-NS041811 and RO1-NS48598), the Julie’s Hope Award from the Citizens United for Research in Epilepsy, and the Dr. Michel and Mrs. Anna Mirowski Discovery Fund for Epilepsy Research. J.V. received a Ruth L. Kirschstein National Research Service Award (2T32HL007954) from the US National Institutes of Health, National Heart, Lung and Blood Institute.

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AB - Arrays of electrodes for recording and stimulating the brain are used throughout clinical medicine and basic neuroscience research, yet are unable to sample large areas of the brain while maintaining high spatial resolution because of the need to individually wire each passive sensor at the electrode-tissue interface. To overcome this constraint, we developed new devices that integrate ultrathin and flexible silicon nanomembrane transistors into the electrode array, enabling new dense arrays of thousands of amplified and multiplexed sensors that are connected using fewer wires. We used this system to record spatial properties of cat brain activity in vivo, including sleep spindles, single-trial visual evoked responses and electrographic seizures. We found that seizures may manifest as recurrent spiral waves that propagate in the neocortex. The developments reported here herald a new generation of diagnostic and therapeutic brain-machine interface devices.

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Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo

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