Flexible Transient Optical Waveguides and Surface-Wave Biosensors Constructed from Monocrystalline Silicon

Wubin Bai, Hongjun Yang, Yinji Ma, Hao Chen, Jiho Shin, Yonghao Liu, Quansan Yang, Irawati Kandela, Zhonghe Liu, Seung Kyun Kang, Chen Wei, Chad R Haney, Anlil Brikha, Xiaochen Ge, Xue Feng, Paul V. Braun, Yonggang Huang, Weidong Zhou*, John A Rogers

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Optical technologies offer important capabilities in both biological research and clinical care. Recent interest is in implantable devices that provide intimate optical coupling to biological tissues for a finite time period and then undergo full bioresorption into benign products, thereby serving as temporary implants for diagnosis and/or therapy. The results presented here establish a silicon-based, bioresorbable photonic platform that relies on thin filaments of monocrystalline silicon encapsulated by polymers as flexible, transient optical waveguides for accurate light delivery and sensing at targeted sites in biological systems. Comprehensive studies of the mechanical and optical properties associated with bending and unfurling the waveguides from wafer-scale sources of materials establish general guidelines in fabrication and design. Monitoring biochemical species such as glucose and tracking physiological parameters such as oxygen saturation using near-infrared spectroscopic methods demonstrate modes of utility in biomedicine. These concepts provide versatile capabilities in biomedical diagnosis, therapy, deep-tissue imaging, and surgery, and suggest a broad range of opportunities for silicon photonics in bioresorbable technologies.

Original languageEnglish (US)
Article number1801584
JournalAdvanced Materials
Volume30
Issue number32
DOIs
StatePublished - Aug 9 2018

Fingerprint

Monocrystalline silicon
Optical waveguides
Silicon
Biosensors
Surface waves
Photonics
Tissue
Biological systems
Surgery
Glucose
Polymers
Waveguides
Optical properties
Oxygen
Infrared radiation
Imaging techniques
Fabrication
Mechanical properties
Monitoring

Keywords

  • flexible photonics
  • silicon nanomembrane
  • spectroscopy
  • transfer printing
  • transient photonics

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Bai, Wubin ; Yang, Hongjun ; Ma, Yinji ; Chen, Hao ; Shin, Jiho ; Liu, Yonghao ; Yang, Quansan ; Kandela, Irawati ; Liu, Zhonghe ; Kang, Seung Kyun ; Wei, Chen ; Haney, Chad R ; Brikha, Anlil ; Ge, Xiaochen ; Feng, Xue ; Braun, Paul V. ; Huang, Yonggang ; Zhou, Weidong ; Rogers, John A. / Flexible Transient Optical Waveguides and Surface-Wave Biosensors Constructed from Monocrystalline Silicon. In: Advanced Materials. 2018 ; Vol. 30, No. 32.
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abstract = "Optical technologies offer important capabilities in both biological research and clinical care. Recent interest is in implantable devices that provide intimate optical coupling to biological tissues for a finite time period and then undergo full bioresorption into benign products, thereby serving as temporary implants for diagnosis and/or therapy. The results presented here establish a silicon-based, bioresorbable photonic platform that relies on thin filaments of monocrystalline silicon encapsulated by polymers as flexible, transient optical waveguides for accurate light delivery and sensing at targeted sites in biological systems. Comprehensive studies of the mechanical and optical properties associated with bending and unfurling the waveguides from wafer-scale sources of materials establish general guidelines in fabrication and design. Monitoring biochemical species such as glucose and tracking physiological parameters such as oxygen saturation using near-infrared spectroscopic methods demonstrate modes of utility in biomedicine. These concepts provide versatile capabilities in biomedical diagnosis, therapy, deep-tissue imaging, and surgery, and suggest a broad range of opportunities for silicon photonics in bioresorbable technologies.",
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author = "Wubin Bai and Hongjun Yang and Yinji Ma and Hao Chen and Jiho Shin and Yonghao Liu and Quansan Yang and Irawati Kandela and Zhonghe Liu and Kang, {Seung Kyun} and Chen Wei and Haney, {Chad R} and Anlil Brikha and Xiaochen Ge and Xue Feng and Braun, {Paul V.} and Yonggang Huang and Weidong Zhou and Rogers, {John A}",
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Bai, W, Yang, H, Ma, Y, Chen, H, Shin, J, Liu, Y, Yang, Q, Kandela, I, Liu, Z, Kang, SK, Wei, C, Haney, CR, Brikha, A, Ge, X, Feng, X, Braun, PV, Huang, Y, Zhou, W & Rogers, JA 2018, 'Flexible Transient Optical Waveguides and Surface-Wave Biosensors Constructed from Monocrystalline Silicon', Advanced Materials, vol. 30, no. 32, 1801584. https://doi.org/10.1002/adma.201801584

Flexible Transient Optical Waveguides and Surface-Wave Biosensors Constructed from Monocrystalline Silicon. / Bai, Wubin; Yang, Hongjun; Ma, Yinji; Chen, Hao; Shin, Jiho; Liu, Yonghao; Yang, Quansan; Kandela, Irawati; Liu, Zhonghe; Kang, Seung Kyun; Wei, Chen; Haney, Chad R; Brikha, Anlil; Ge, Xiaochen; Feng, Xue; Braun, Paul V.; Huang, Yonggang; Zhou, Weidong; Rogers, John A.

In: Advanced Materials, Vol. 30, No. 32, 1801584, 09.08.2018.

Research output: Contribution to journalArticle

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T1 - Flexible Transient Optical Waveguides and Surface-Wave Biosensors Constructed from Monocrystalline Silicon

AU - Bai, Wubin

AU - Yang, Hongjun

AU - Ma, Yinji

AU - Chen, Hao

AU - Shin, Jiho

AU - Liu, Yonghao

AU - Yang, Quansan

AU - Kandela, Irawati

AU - Liu, Zhonghe

AU - Kang, Seung Kyun

AU - Wei, Chen

AU - Haney, Chad R

AU - Brikha, Anlil

AU - Ge, Xiaochen

AU - Feng, Xue

AU - Braun, Paul V.

AU - Huang, Yonggang

AU - Zhou, Weidong

AU - Rogers, John A

PY - 2018/8/9

Y1 - 2018/8/9

N2 - Optical technologies offer important capabilities in both biological research and clinical care. Recent interest is in implantable devices that provide intimate optical coupling to biological tissues for a finite time period and then undergo full bioresorption into benign products, thereby serving as temporary implants for diagnosis and/or therapy. The results presented here establish a silicon-based, bioresorbable photonic platform that relies on thin filaments of monocrystalline silicon encapsulated by polymers as flexible, transient optical waveguides for accurate light delivery and sensing at targeted sites in biological systems. Comprehensive studies of the mechanical and optical properties associated with bending and unfurling the waveguides from wafer-scale sources of materials establish general guidelines in fabrication and design. Monitoring biochemical species such as glucose and tracking physiological parameters such as oxygen saturation using near-infrared spectroscopic methods demonstrate modes of utility in biomedicine. These concepts provide versatile capabilities in biomedical diagnosis, therapy, deep-tissue imaging, and surgery, and suggest a broad range of opportunities for silicon photonics in bioresorbable technologies.

AB - Optical technologies offer important capabilities in both biological research and clinical care. Recent interest is in implantable devices that provide intimate optical coupling to biological tissues for a finite time period and then undergo full bioresorption into benign products, thereby serving as temporary implants for diagnosis and/or therapy. The results presented here establish a silicon-based, bioresorbable photonic platform that relies on thin filaments of monocrystalline silicon encapsulated by polymers as flexible, transient optical waveguides for accurate light delivery and sensing at targeted sites in biological systems. Comprehensive studies of the mechanical and optical properties associated with bending and unfurling the waveguides from wafer-scale sources of materials establish general guidelines in fabrication and design. Monitoring biochemical species such as glucose and tracking physiological parameters such as oxygen saturation using near-infrared spectroscopic methods demonstrate modes of utility in biomedicine. These concepts provide versatile capabilities in biomedical diagnosis, therapy, deep-tissue imaging, and surgery, and suggest a broad range of opportunities for silicon photonics in bioresorbable technologies.

KW - flexible photonics

KW - silicon nanomembrane

KW - spectroscopy

KW - transfer printing

KW - transient photonics

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