Flexible Transient Optical Waveguides and Surface-Wave Biosensors Constructed from Monocrystalline Silicon

Wubin Bai; Hongjun Yang; Yinji Ma; Hao Chen; Jiho Shin; Yonghao Liu; Quansan Yang; Irawati Kandela; Zhonghe Liu; Seung Kyun Kang; Chen Wei; Chad R. Haney; Anlil Brikha; Xiaochen Ge; Xue Feng; Paul V. Braun; Yonggang Huang; Weidong Zhou; John A. Rogers

doi:10.1002/adma.201801584

Flexible Transient Optical Waveguides and Surface-Wave Biosensors Constructed from Monocrystalline Silicon

Wubin Bai, Hongjun Yang, Yinji Ma, Hao Chen, Jiho Shin, Yonghao Liu, Quansan Yang, Irawati Kandela, Zhonghe Liu, Seung Kyun Kang, Chen Wei, Chad R. Haney, Anlil Brikha, Xiaochen Ge, Xue Feng, Paul V. Braun, Yonggang Huang, Weidong Zhou^*, John A. Rogers

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Optical technologies offer important capabilities in both biological research and clinical care. Recent interest is in implantable devices that provide intimate optical coupling to biological tissues for a finite time period and then undergo full bioresorption into benign products, thereby serving as temporary implants for diagnosis and/or therapy. The results presented here establish a silicon-based, bioresorbable photonic platform that relies on thin filaments of monocrystalline silicon encapsulated by polymers as flexible, transient optical waveguides for accurate light delivery and sensing at targeted sites in biological systems. Comprehensive studies of the mechanical and optical properties associated with bending and unfurling the waveguides from wafer-scale sources of materials establish general guidelines in fabrication and design. Monitoring biochemical species such as glucose and tracking physiological parameters such as oxygen saturation using near-infrared spectroscopic methods demonstrate modes of utility in biomedicine. These concepts provide versatile capabilities in biomedical diagnosis, therapy, deep-tissue imaging, and surgery, and suggest a broad range of opportunities for silicon photonics in bioresorbable technologies.

Original language	English (US)
Article number	1801584
Journal	Advanced Materials
Volume	30
Issue number	32
DOIs	https://doi.org/10.1002/adma.201801584
State	Published - Aug 9 2018

Funding

W.B. and H.Y. contributed equally to this work. W.Z. acknowledges support from Army Research Office under Grant No. W911NF-15-1-0035. Y.M. and X.F. acknowledge the support from the National Basic Research Program of China (Grant No. 2015CB351900) and the National Natural Science Foundation of China (Grant Nos. 11402135 and 11320101001). Y.H. acknowledges the support from National Science Foundation (Grant Nos. 1400169, 1534120, and 1635443) and National Institutes of Health (Grant No. R01EB019337). This work utilized Northwestern University Micro/Nano Fabrication Facility (NUFAB), which was partially supported by Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205), the Materials Research Science and Engineering Center (NSF DMR-1121262), the State of Illinois, Northwestern University, and the Center for Bio-Integrated Electronics at the Simpson/Querrey Institute. The Center for Developmental Therapeutics was supported by Cancer Center Support Grant P30 CA060553 from the National Cancer Institute awarded to the Robert H. Lurie Comprehensive Cancer Center.

Keywords

flexible photonics
silicon nanomembrane
spectroscopy
transfer printing
transient photonics

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

Access to Document

10.1002/adma.201801584

Cite this

Bai, W., Yang, H., Ma, Y., Chen, H., Shin, J., Liu, Y., Yang, Q., Kandela, I., Liu, Z., Kang, S. K., Wei, C., Haney, C. R., Brikha, A., Ge, X., Feng, X., Braun, P. V., Huang, Y., Zhou, W., & Rogers, J. A. (2018). Flexible Transient Optical Waveguides and Surface-Wave Biosensors Constructed from Monocrystalline Silicon. Advanced Materials, 30(32), Article 1801584. https://doi.org/10.1002/adma.201801584

@article{c75edf7762b5439b9b3af266b21a4b9d,

title = "Flexible Transient Optical Waveguides and Surface-Wave Biosensors Constructed from Monocrystalline Silicon",

abstract = "Optical technologies offer important capabilities in both biological research and clinical care. Recent interest is in implantable devices that provide intimate optical coupling to biological tissues for a finite time period and then undergo full bioresorption into benign products, thereby serving as temporary implants for diagnosis and/or therapy. The results presented here establish a silicon-based, bioresorbable photonic platform that relies on thin filaments of monocrystalline silicon encapsulated by polymers as flexible, transient optical waveguides for accurate light delivery and sensing at targeted sites in biological systems. Comprehensive studies of the mechanical and optical properties associated with bending and unfurling the waveguides from wafer-scale sources of materials establish general guidelines in fabrication and design. Monitoring biochemical species such as glucose and tracking physiological parameters such as oxygen saturation using near-infrared spectroscopic methods demonstrate modes of utility in biomedicine. These concepts provide versatile capabilities in biomedical diagnosis, therapy, deep-tissue imaging, and surgery, and suggest a broad range of opportunities for silicon photonics in bioresorbable technologies.",

keywords = "flexible photonics, silicon nanomembrane, spectroscopy, transfer printing, transient photonics",

author = "Wubin Bai and Hongjun Yang and Yinji Ma and Hao Chen and Jiho Shin and Yonghao Liu and Quansan Yang and Irawati Kandela and Zhonghe Liu and Kang, {Seung Kyun} and Chen Wei and Haney, {Chad R.} and Anlil Brikha and Xiaochen Ge and Xue Feng and Braun, {Paul V.} and Yonggang Huang and Weidong Zhou and Rogers, {John A.}",

note = "Funding Information: W.B. and H.Y. contributed equally to this work. W.Z. acknowledges support from Army Research Office under Grant No. W911NF-15-1-0035. Y.M. and X.F. acknowledge the support from the National Basic Research Program of China (Grant No. 2015CB351900) and the National Natural Science Foundation of China (Grant Nos. 11402135 and 11320101001). Y.H. acknowledges the support from National Science Foundation (Grant Nos. 1400169, 1534120, and 1635443) and National Institutes of Health (Grant No. R01EB019337). This work utilized Northwestern University Micro/Nano Fabrication Facility (NUFAB), which was partially supported by Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205), the Materials Research Science and Engineering Center (NSF DMR-1121262), the State of Illinois, Northwestern University, and the Center for Bio-Integrated Electronics at the Simpson/Querrey Institute. The Center for Developmental Therapeutics was supported by Cancer Center Support Grant P30 CA060553 from the National Cancer Institute awarded to the Robert H. Lurie Comprehensive Cancer Center. Publisher Copyright: {\textcopyright} 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2018",

month = aug,

day = "9",

doi = "10.1002/adma.201801584",

language = "English (US)",

volume = "30",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-Blackwell",

number = "32",

}

Bai, W, Yang, H, Ma, Y, Chen, H, Shin, J, Liu, Y, Yang, Q, Kandela, I, Liu, Z, Kang, SK, Wei, C, Haney, CR, Brikha, A, Ge, X, Feng, X, Braun, PV, Huang, Y, Zhou, W & Rogers, JA 2018, 'Flexible Transient Optical Waveguides and Surface-Wave Biosensors Constructed from Monocrystalline Silicon', Advanced Materials, vol. 30, no. 32, 1801584. https://doi.org/10.1002/adma.201801584

TY - JOUR

T1 - Flexible Transient Optical Waveguides and Surface-Wave Biosensors Constructed from Monocrystalline Silicon

AU - Bai, Wubin

AU - Yang, Hongjun

AU - Ma, Yinji

AU - Chen, Hao

AU - Shin, Jiho

AU - Liu, Yonghao

AU - Yang, Quansan

AU - Kandela, Irawati

AU - Liu, Zhonghe

AU - Kang, Seung Kyun

AU - Wei, Chen

AU - Haney, Chad R.

AU - Brikha, Anlil

AU - Ge, Xiaochen

AU - Feng, Xue

AU - Braun, Paul V.

AU - Huang, Yonggang

AU - Zhou, Weidong

AU - Rogers, John A.

N1 - Funding Information: W.B. and H.Y. contributed equally to this work. W.Z. acknowledges support from Army Research Office under Grant No. W911NF-15-1-0035. Y.M. and X.F. acknowledge the support from the National Basic Research Program of China (Grant No. 2015CB351900) and the National Natural Science Foundation of China (Grant Nos. 11402135 and 11320101001). Y.H. acknowledges the support from National Science Foundation (Grant Nos. 1400169, 1534120, and 1635443) and National Institutes of Health (Grant No. R01EB019337). This work utilized Northwestern University Micro/Nano Fabrication Facility (NUFAB), which was partially supported by Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205), the Materials Research Science and Engineering Center (NSF DMR-1121262), the State of Illinois, Northwestern University, and the Center for Bio-Integrated Electronics at the Simpson/Querrey Institute. The Center for Developmental Therapeutics was supported by Cancer Center Support Grant P30 CA060553 from the National Cancer Institute awarded to the Robert H. Lurie Comprehensive Cancer Center. Publisher Copyright: © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2018/8/9

Y1 - 2018/8/9

N2 - Optical technologies offer important capabilities in both biological research and clinical care. Recent interest is in implantable devices that provide intimate optical coupling to biological tissues for a finite time period and then undergo full bioresorption into benign products, thereby serving as temporary implants for diagnosis and/or therapy. The results presented here establish a silicon-based, bioresorbable photonic platform that relies on thin filaments of monocrystalline silicon encapsulated by polymers as flexible, transient optical waveguides for accurate light delivery and sensing at targeted sites in biological systems. Comprehensive studies of the mechanical and optical properties associated with bending and unfurling the waveguides from wafer-scale sources of materials establish general guidelines in fabrication and design. Monitoring biochemical species such as glucose and tracking physiological parameters such as oxygen saturation using near-infrared spectroscopic methods demonstrate modes of utility in biomedicine. These concepts provide versatile capabilities in biomedical diagnosis, therapy, deep-tissue imaging, and surgery, and suggest a broad range of opportunities for silicon photonics in bioresorbable technologies.

AB - Optical technologies offer important capabilities in both biological research and clinical care. Recent interest is in implantable devices that provide intimate optical coupling to biological tissues for a finite time period and then undergo full bioresorption into benign products, thereby serving as temporary implants for diagnosis and/or therapy. The results presented here establish a silicon-based, bioresorbable photonic platform that relies on thin filaments of monocrystalline silicon encapsulated by polymers as flexible, transient optical waveguides for accurate light delivery and sensing at targeted sites in biological systems. Comprehensive studies of the mechanical and optical properties associated with bending and unfurling the waveguides from wafer-scale sources of materials establish general guidelines in fabrication and design. Monitoring biochemical species such as glucose and tracking physiological parameters such as oxygen saturation using near-infrared spectroscopic methods demonstrate modes of utility in biomedicine. These concepts provide versatile capabilities in biomedical diagnosis, therapy, deep-tissue imaging, and surgery, and suggest a broad range of opportunities for silicon photonics in bioresorbable technologies.

KW - flexible photonics

KW - silicon nanomembrane

KW - spectroscopy

KW - transfer printing

KW - transient photonics

UR - http://www.scopus.com/inward/record.url?scp=85051107434&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051107434&partnerID=8YFLogxK

U2 - 10.1002/adma.201801584

DO - 10.1002/adma.201801584

M3 - Article

C2 - 29944186

AN - SCOPUS:85051107434

SN - 0935-9648

VL - 30

JO - Advanced Materials

JF - Advanced Materials

IS - 32

M1 - 1801584

ER -

Flexible Transient Optical Waveguides and Surface-Wave Biosensors Constructed from Monocrystalline Silicon

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this