Flexion synergy overshadows flexor spasticity during reaching in chronic moderate to severe hemiparetic stroke

Michael D. Ellis*, Ingrid Schut, Julius P.A. Dewald

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Objective Pharmaceutical intervention targets arm flexor spasticity with an often-unsuccessful goal of improving function. Flexion synergy is a related motor impairment that may be inadvertently neglected. Here, flexor spasticity and flexion synergy are disentangled to determine their contributions to reaching dysfunction. Methods Twenty-six individuals participated. A robotic device systematically modulated shoulder abduction loading during ballistic reaching. Elbow muscle electromyography data were partitioned into windows delineated by elbow joint velocity allowing for the separation of synergy- and spasticity-related activation. Results Reaching velocity decreased with abduction loading (p < 0.001) such that velocity was 30% slower when lifting the arm at 50% of abduction strength compared to when arm weight was supported. Abnormal flexion synergy increased with abduction loading (p < 0.001) such that normalized activation ranged from a median (interquartile range) of 0.07 (0.03–0.12) when arm weight was supported to 0.19 (0.12–0.40) when actively lifting (large effect size, d = 0.59). Flexor spasticity was detected during reaching (p = 0.016) but only when arm weight was supported (intermediate effect size, d = 0.33). Conclusion Flexion synergy is the predominant contributor to reaching dysfunction while flexor spasticity appears only relevant during unnaturally occurring passively supported movement. Significance Interventions targeting flexion synergy should be leveraged in future stroke recovery trials.

Original languageEnglish (US)
Pages (from-to)1308-1314
Number of pages7
JournalClinical Neurophysiology
Volume128
Issue number7
DOIs
StatePublished - Jul 2017

Keywords

  • Arm
  • Biomechanical phenomena
  • Movement
  • Muscles
  • Neurology
  • Rehabilitation
  • Robotics
  • Stroke

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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