Flow cytometric DNA analysis of medulloblastoma. Prognostic implication of aneuploidy

Tadanori Tomita*, Masaharu Yasue, Herbert H. Engelhard, David G McLone, Frank Gonzalez‐Crussi, Kenneth D. Bauer

*Corresponding author for this work

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Paraffin‐embedded surgical specimens from 26 infants and children with medulloblastomas treated between 1972 and 1981 were examined for DNA ploidy by flow cytometry (FCM). All patients received a standard treatment (a combination of maximum debulking of medulloblastoma and postoperative craniospinal irradiation with a posterior fossa boost of 5000 rad or more). They were studied to correlate the results of the findings of FCM DNA analysis with their final outcome, DNA ploidy, and extent of tumor resection. All seven patients with totally resected aneuploid medulloblastoma are alive, whereas only one of six patients with subtotally resected diploid medulloblastoma is alive (P = 0.0047). The current study suggests both DNA ploidy and extent of surgical resection are the most important determinant of patients' prognosis. Patients in selected group, particularly those with subtotally resected diploid tumor, are advised to undergo aggressive adjuvant chemotherapy.

Original languageEnglish (US)
Pages (from-to)744-749
Number of pages6
JournalCancer
Volume61
Issue number4
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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