Fluctuations and supercoiling of DNA

John F. Marko*, Eric D. Siggia

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

192 Scopus citations


Frequently, DNA in vivo is organized into loops that are partially underwound and consequently form interwound helical supercoils. Methods from polymer statistical mechanics are used to show how the competition between entropy (thermal fluctuations) and elastic energy determines supercoil radius and pitch, in good agreement with recent experiments and simulations. Supercoil reorganization by means of slithering (reptation) of the DNA along the supercoil is argued to be a stow process. Extension of supercoiled DNA by an applied force shows a number of unexpected features, including coexistence of interwound and helical states.

Original languageEnglish (US)
Pages (from-to)506-508
Number of pages3
Issue number5171
StatePublished - 1994

ASJC Scopus subject areas

  • General


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