Fludrocortisone improves nausea in children with orthostatic intolerance (OI)

John E. Fortunato*, Hossam A. Shaltout, Megan M. Larkin, Peter C. Rowe, Debra I. Diz, Kenneth L. Koch

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Introduction/Results: In 17 patients, chronic idiopathic nausea was associated with orthostatic intolerance (OI) by abnormal tilt table tests (88%) or gastric dysrhythmias (71%). After fludrocortisone treatment, there was >26% nausea improvement in 71%, 1-25% in 6%, and no improvement in 24%. In six subjects, EGGs repeated after >50% nausea improvement all remained to be abnormal, suggesting nausea is independent of gastric dysrhythmias. Conclusion: Association of EGG abnormalities and OI in this subset of nausea patients suggests a generalized disturbance of autonomic regulation.

Original languageEnglish (US)
Pages (from-to)419-423
Number of pages5
JournalClinical Autonomic Research
Volume21
Issue number6
DOIs
StatePublished - Dec 1 2011

Keywords

  • Electrogastrography
  • Fludrocortisone acetate chronic idiopathic nausea
  • Neurally mediated hypotension (NMH)
  • Orthostatic intolerance (OI)
  • Postural orthostatic tachycardia syndrome (POTS)
  • Tilt table testing

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology

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