Fluid dynamics model of mitral valve flow: Description with initial in vitro and clinical validation

James D. Thomas*, Gerard T. Wilkins, Christopher Y P Choong, Robert A. Levine, Arthur E. Weyman

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

3 Scopus citations


The authors have devised a lumped-parameter fluid-dynamics model of mitral valve blood flow applicable both to Doppler echocardiography and invasive hemodynamic measurement. Given left atrial and ventricular compliance, initial pressures, and mitral valve impedance, the model predicts the time course of mitral flow and atrial and ventricular pressure. The model has been implemented in computer simulation and in an in vitro analog. For the in vitro model, observed pressure decay curves correlated with predicted curves with r > 0.99 in all cases. Furthermore, for a range of orifice area, 0.3-3.0 cm2, initial pressure gradient, 2.4-14.2 mmHg, and net chamber compliance, 17.2-30.3 cm3/mmHg, the mathematical construct was able to predict the observed rate of pressure decay with r = 0.9987. More clinically useful would be an inversion of the current model equations, to derive information on chamber compliance and valve impedance from observed pressure and flow curves. This appears to be technically feasible and an approach is described.

Original languageEnglish (US)
Pages (from-to)211-214
Number of pages4
JournalComputers in Cardiology
StatePublished - Dec 1 1987

ASJC Scopus subject areas

  • Computer Science Applications
  • Cardiology and Cardiovascular Medicine


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