TY - JOUR
T1 - Fluid dynamics model of mitral valve flow
T2 - Description with initial in vitro and clinical validation
AU - Thomas, James D.
AU - Wilkins, Gerard T.
AU - Choong, Christopher Y P
AU - Levine, Robert A.
AU - Weyman, Arthur E.
PY - 1987
Y1 - 1987
N2 - The authors have devised a lumped-parameter fluid-dynamics model of mitral valve blood flow applicable both to Doppler echocardiography and invasive hemodynamic measurement. Given left atrial and ventricular compliance, initial pressures, and mitral valve impedance, the model predicts the time course of mitral flow and atrial and ventricular pressure. The model has been implemented in computer simulation and in an in vitro analog. For the in vitro model, observed pressure decay curves correlated with predicted curves with r > 0.99 in all cases. Furthermore, for a range of orifice area, 0.3-3.0 cm2, initial pressure gradient, 2.4-14.2 mmHg, and net chamber compliance, 17.2-30.3 cm3/mmHg, the mathematical construct was able to predict the observed rate of pressure decay with r = 0.9987. More clinically useful would be an inversion of the current model equations, to derive information on chamber compliance and valve impedance from observed pressure and flow curves. This appears to be technically feasible and an approach is described.
AB - The authors have devised a lumped-parameter fluid-dynamics model of mitral valve blood flow applicable both to Doppler echocardiography and invasive hemodynamic measurement. Given left atrial and ventricular compliance, initial pressures, and mitral valve impedance, the model predicts the time course of mitral flow and atrial and ventricular pressure. The model has been implemented in computer simulation and in an in vitro analog. For the in vitro model, observed pressure decay curves correlated with predicted curves with r > 0.99 in all cases. Furthermore, for a range of orifice area, 0.3-3.0 cm2, initial pressure gradient, 2.4-14.2 mmHg, and net chamber compliance, 17.2-30.3 cm3/mmHg, the mathematical construct was able to predict the observed rate of pressure decay with r = 0.9987. More clinically useful would be an inversion of the current model equations, to derive information on chamber compliance and valve impedance from observed pressure and flow curves. This appears to be technically feasible and an approach is described.
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M3 - Conference article
AN - SCOPUS:0023458492
SN - 0276-6574
SP - 211
EP - 214
JO - Computers in Cardiology
JF - Computers in Cardiology
ER -