Fluorescein fundus angiographic findings in Vogt-Koyanagi-Harada syndrome

Purpose: To report the fluorescein fundus angiographic (FFA) findings in the different clinical stages of Vogt-Koyanagi-Harada (VKH) patients. Methods: Retrospective, transversal and descriptive study. All patients underwent FFA at least in one occasion. Patients with incomplete clinical files or a deficient FFA were excluded. We divided the patients in four groups, depending on their clinical stage at the time of the study: acute uveitic stage, chronic uveitis stage, convalescent stage and recurrence stage. We correlated the frequency and statistical significance of eleven angiographic patterns with their corresponding clinical stages. Results: The files of 60 patients were reviewed. Most common findings in the acute uveitis stage were: disseminated spotted choroidal hyperfluorescence and choroidal hypofluorescence. In the chronic uveitic stage: spotted hyper and hypofluorescence and optic disc hyperfluorescence. In the convalescent stage: spotted hyper and hypofluorescence and blockage of choroidal fluorescence. Retinal vasculitis was found more frequently than in previous reports. A reticular hypofluorescent pattern with no clinical correlation was found. Conclusions: The angiographic findings of VKH syndrome change asthe disease progress along different clinical stages. Recognition of those different patterns helps the clinician to diagnose the disease during all its stages.