Fluorescence properties of curcumin-loaded nanoparticles for cell tracking

Bassam Felipe Mogharbel, Julio Cesar Francisco, Ana Carolina Irioda, Dilcele Silva Moreira Dziedzic, Priscila Elias Ferreira, Daiany de Souza, Carolina Maria Costa Oliveira de Souza, Nelson Bergonse Neto, Luiz Cesar Guarita-Souza, Celia Regina Cavichiolo Franco, Celso Vataru Nakamura, Vanessa Kaplum, Letícia Mazzarino, Elenara Lemos-Senna, Redouane Borsali, Paula A. Soto, Patricia Setton-Avruj, Eltyeb Abdelwahid, Katherine Athayde Teixeira de Carvalho

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Background: Posttransplant cell tracking, via stem cell labeling, is a crucial strategy for monitoring and maximizing benefits of cell-based therapies. The structures and functionalities of polysaccharides, proteins, and lipids allow their utilization in nanotechnology systems. Materials and methods: In the present study, we analyzed the potential benefit of curcumin-loaded nanoparticles (NPC) using Vero cells (in vitro) and NPC-labeled adipose-derived mesenchymal stem cells (NPC-ADMSCs) (in vivo) in myocardial infarction and sciatic nerve crush preclinical models. Thereafter, transplantation, histological examination, real time imaging, and assessment of tissue regeneration were done. Results: Transplanted NPC-ADMSCs were clearly identified and revealed potential benefit when used in cell tracking. Conclusion: This approach may have broad applications in modeling labeled transplanted cells and in developing improved stem cell therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)5823-5836
Number of pages14
JournalInternational Journal of Nanomedicine
StatePublished - 2018


  • Cell marking
  • Mesenchymal stem cells
  • Myocardium infarction
  • Sciatic nerve crush
  • Transplantation

ASJC Scopus subject areas

  • Drug Discovery
  • Bioengineering
  • Biophysics
  • Biomaterials
  • Pharmaceutical Science
  • Organic Chemistry


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