Fluorescence spectroscopy of endomyocardial tissue post-human heart transplantation: Does it correlate with histopathology?

Mohamad H. Yamani*, Sweder W E Van De Poll, Norman B. Ratliff, Barry E. Kuban, Randall C. Starling, Patrick M. McCarthy, James B. Young

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background: A significant correlation between autofluorescence spectroscopy and heart allograft rejection has been described in the rat heterotropic allograft model. However, the use of this technique in human heart transplants has not been validate. Methods: We obtained fluorescence and reflectance spectra on 37 human endomyocardial biopsy specimens and correlated the spectra with International Society Heart and Lung Transplantation grade for histologic rejection. Results: Using different excitation wavelengths (ultraviolet, λ = 337 nm; blue, λ = 440 nm, and green, λ = 486 nm), we found no significant difference in the fluorescence spectra among the different grades of rejection. Conclusions: Fluorescence spectroscopy is not a sensitive method for detecting rejection in human heart transplant recipients.

Original languageEnglish (US)
Pages (from-to)1077-1080
Number of pages4
JournalJournal of Heart and Lung Transplantation
Volume19
Issue number11
DOIs
StatePublished - Nov 25 2000

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

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