Fluorocarbon Modified Low-Molecular-Weight Polyethylenimine for siRNA Delivery

Mark E. Johnson, Judy Shon, Brian M. Guan, Joseph P. Patterson, Nathan J. Oldenhuis, Alexander C. Eldredge, Nathan C. Gianneschi, Zhibin Guan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


We report the synthesis and study of fluorocarbon (FC) modified polyethylenimine (PEI) for the purpose of siRNA delivery. Low-molecular-weight PEI (Mn = 600) was functionalized with fluorocarbon epoxides of varying length. All FC-modified samples with greater than 2.0 equiv of FC epoxide per PEI induced potent gene silencing in vitro. Compared to hydrocarbon (HC) analogues, the FC vectors showed greater general silencing efficacy, higher cell uptake, and reduced association with serum components. Collectively, the data suggest that modification of polyamines with FCs is a promising approach for the discovery of novel vectors for siRNA delivery.

Original languageEnglish (US)
Pages (from-to)1784-1788
Number of pages5
JournalBioconjugate Chemistry
Issue number8
StatePublished - Aug 17 2016

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry


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