Fluoroquinolone resistance is a poor surrogate marker for type II topoisomerase mutations in clinical isolates of Streptococcus pneumoniae

J. J. Millichap, E. Pestova, F. Siddiqui, G. A. Noskin, L. R. Peterson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The association between fluoroquinolone susceptibility and DNA mutations coding for amino acid substitutions in the quinolone resistance-determining region was assessed with 44 clinical isolates of Streptococcus pneumoniae. Twenty-three strains bore at least one amino acid substitution. Only seven strains with mutations were suggested by diminished susceptibility to ciprofloxacin (MIC, ≥2 μg/ml).

Original languageEnglish (US)
Pages (from-to)2719-2721
Number of pages3
JournalJournal of clinical microbiology
Volume39
Issue number7
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Microbiology (medical)

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