Fluvastatin protects cochleae from damage by high-level noise

Claus-Peter Richter, Hunter Young, Sonja V. Richter, Virginia Smith-Bronstein, Stuart R Stock, Xianghui Xiao, Carmen Soriano, Donna S Whitlon*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Exposure to noise and ototoxic drugs are responsible for much of the debilitating hearing loss experienced by about 350 million people worldwide. Beyond hearing aids and cochlear implants, there have been no other FDA approved drug interventions established in the clinic that would either protect or reverse the effects of hearing loss. Using Auditory Brainstem Responses (ABR) in a Guinea pig model, we demonstrate that fluvastatin, an inhibitor of HMG-CoA reductase, the rate-limiting enzyme of the mevalonate pathway, protects against loss of cochlear function initiated by high intensity noise. A novel synchrotron radiation based X-ray tomographic method that imaged soft tissues at micrometer resolution in unsectioned cochleae, allowed an efficient, qualitative evaluation of the three-dimensional internal structure of the intact organ. For quantitative measures, plastic embedded cochleae were sectioned followed by hair cell counting. Protection in noise-exposed cochleae is associated with retention of inner and outer hair cells. This study demonstrates the potential of HMG-CoA reductase inhibitors, already vetted in human medicine for other purposes, to protect against noise induced hearing loss.

Original languageEnglish (US)
Article number3033
JournalScientific reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

Fingerprint

fluvastatin
Cochlea
Noise
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hearing Loss
Outer Auditory Hair Cells
Inner Auditory Hair Cells
Noise-Induced Hearing Loss
Mevalonic Acid
Synchrotrons
Hearing Aids
Cochlear Implants
Brain Stem Auditory Evoked Potentials
Pharmaceutical Preparations
Plastics
Guinea Pigs
X-Rays
Medicine
Radiation
Enzymes

ASJC Scopus subject areas

  • General

Cite this

Richter, Claus-Peter ; Young, Hunter ; Richter, Sonja V. ; Smith-Bronstein, Virginia ; Stock, Stuart R ; Xiao, Xianghui ; Soriano, Carmen ; Whitlon, Donna S. / Fluvastatin protects cochleae from damage by high-level noise. In: Scientific reports. 2018 ; Vol. 8, No. 1.
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Richter, C-P, Young, H, Richter, SV, Smith-Bronstein, V, Stock, SR, Xiao, X, Soriano, C & Whitlon, DS 2018, 'Fluvastatin protects cochleae from damage by high-level noise', Scientific reports, vol. 8, no. 1, 3033. https://doi.org/10.1038/s41598-018-21336-7

Fluvastatin protects cochleae from damage by high-level noise. / Richter, Claus-Peter; Young, Hunter; Richter, Sonja V.; Smith-Bronstein, Virginia; Stock, Stuart R; Xiao, Xianghui; Soriano, Carmen; Whitlon, Donna S.

In: Scientific reports, Vol. 8, No. 1, 3033, 01.12.2018.

Research output: Contribution to journalArticle

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Richter C-P, Young H, Richter SV, Smith-Bronstein V, Stock SR, Xiao X et al. Fluvastatin protects cochleae from damage by high-level noise. Scientific reports. 2018 Dec 1;8(1). 3033. https://doi.org/10.1038/s41598-018-21336-7