FMRI indices of auditory attention in schizophrenia

Todd N. Schirmer*, Jill M. Dorflinger, Megan Marlow-O'Connor, Jo Cara Pendergrass, Aileen Hartzell, Sherrie D. All, David Charles

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The present study sought to identify abnormalities in activation in several brain regions in response to an auditory attention task in patients with schizophrenia. Ten patients and twenty healthy control participants were examined using Functional Magnetic Resonance Imaging (FMRI) measures acquired during an auditory attention task. Region of interest analyses of activation of targeted regions implicated in attention included: anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (DLPFC), hippocampus, parahippocampal gyrus (PHG), and superior temporal gyrus (STG). The results indicated over-activation in patients with schizophrenia. While the control group showed notable coherence in activation within and across hemispheres the schizophrenia group showed relatively less coherence overall that was only present in the right hemisphere. These findings suggest that patients with schizophrenia show both an over-engagement of brain regions during attention task as well as a lack of communication among neural regions involved.

Original languageEnglish (US)
Pages (from-to)25-32
Number of pages8
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume33
Issue number1
DOIs
StatePublished - Feb 1 2009

Keywords

  • Attention
  • Auditory
  • FMRI
  • Frontal lobe
  • Over-activation
  • Temporal lobe

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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