fMRI of visual system activation in the conscious rabbit

Alice M. Wyrwicz*, Nan Kuei Chen, Min Li, Craig Weiss, John F. Disterhoft

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

A conscious rabbit preparation developed for fMRI, and the results from visual stimulation studies at a 4.7T magnetic field are described. The rabbit is ideal for these experiments because of its natural tolerance for restraint. High spatial and temporal resolution magnetic resonance images, without movement artifacts, were obtained during long periods of restraint. Functional activation in primary visual cortex and lateral geniculate nucleus (LGN) were reproducibly observed in response to light-stimulus. In comparison to existing anesthetized animal models, a functional response free of the anesthetic modulation can be recorded with the new approach. The conscious animal model can be applied to functional studies of sensory systems, learning and memory, and drug-induced cerebral activation. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)474-478
Number of pages5
JournalMagnetic resonance in medicine
Volume44
Issue number3
DOIs
StatePublished - 2000

Keywords

  • BOLD
  • Conscious animal model
  • Functional activations
  • Visual cortex
  • fMRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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