Focal adhesion kinase signaling and the aggressive melanoma phenotype

Angela R. Hess, Mary J.C. Hendrix*

*Corresponding author for this work

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Focal adhesion kinase (FAK) mediates myriad cellular functions and has been found to be overexpressed in numerous human cancers. We recently explored the role of FAK in promoting the aggressive phenotype of melanoma cells, characterized by increased invasion, migration, and vasculogenic mimicry (VM) potential. We found FAK to be phosphorylated on its key tyrosine residues (397 and 576) in aggressive melanoma cells cultured on a three-dimensional type 1 collagen matrix in vitro, as well as in radial and vertical growth phase melanomas in situ. Furthermore, expressing FAK-related non-kinase (FRNK) in melanoma cells directly resulted in the inhibition of the aggressive phenotype, as demonstrated by decreased invasion, migration and VM potential, in part by blocking an Erk1/2 mediated signaling pathway. Additional data indicated that increased FAK activity may promote cellular proliferation and anchorage independent growth of aggressive melanoma. Together these observations implicate FAK as a promoter of the aggressive melanoma phenotype, thereby identifying a rational target for therapeutic intervention of malignant melanoma.

Original languageEnglish (US)
Pages (from-to)478-480
Number of pages3
JournalCell Cycle
Volume5
Issue number5
DOIs
StatePublished - Mar 1 2006

Keywords

  • Cell invasion
  • Cell migration
  • Erk1/2
  • Focal adhesion kinase (FAK)
  • Melanoma
  • Proliferation
  • Urokinase
  • Vasculogenic mimicry

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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