Focal organizing pneumonia in patients: Differentiation from solitary bronchioloalveolar carcinoma using dual-energy spectral computed tomography

Guojin Zhang, Yuntai Cao, Jing Zhang, Zhiyong Zhao, Wenjuan Zhang, Lele Huang, Zhuoli Zhang, Junlin Zhou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To explore the utility of dual-energy spectral computed tomography (CT) in the differential diagnosis of focal organizing pneumonia (FOP) and solitary bronchioloalveolar carcinoma (S-BAC). Materials and methods: The institutional review board approved this study and waived the requirement for informed consent. It is a retrospective study. A total of 105 patients (62 with FOP and 43 with S-BAC) enrolled and all patients have contrast enhanced spectral CT including the arterial phase (AP) and venous phase (VP). During AP and VP, CT40 keV, CT70 keV, and CT100 keVvalues, iodine concentration (IC), water concentration (WC), and effective atomic number (Zeff) were measured on monochromatic and iodine-based material decomposition images, and the slope of the spectral curve (λHu) was calculated. The two-sample t-test was used to compare quantitative parameters, and receiver operating characteristic (ROC) curves were generated to calculate diagnostic efficacies. Results: For AP, CT40 keVand CT70 keVvalues, IC, WC, Zeff, λ70 keV, and λ100 keVmeasurements, there were significantly higher in patients with S-BAC than in those with FOP (P < 0.05). However, these quantitative parameters of VP were significantly lower in patients with S-BAC than in those with FOP (P < 0.05). ROC curve analysis revealed that the combination of all quantitative parameters in AP and VP provided the best diagnostic performance in distinguishing S-BAC from FOP (area under the ROC curve, 93.1%; sensitivity, 95.3%; specificity, 77.4%). Conclusions: Dual-energy spectral CT has the potential to identify S-BAC and FOP.

Original languageEnglish (US)
Pages (from-to)3974-3983
Number of pages10
JournalAmerican Journal of Translational Research
Volume12
Issue number7
StatePublished - 2020

Keywords

  • Bronchioloalveolar carcinoma
  • Diagnosis
  • Dual-energy CT
  • Organized pneumonia

ASJC Scopus subject areas

  • Molecular Medicine
  • Clinical Biochemistry
  • Cancer Research

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