Food allergy: Insights into etiology, prevention, and treatment provided by murine models

Michiko K. Oyoshi*, Hans C. Oettgen, Talal A. Chatila, Raif S. Geha, Paul J. Bryce

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

80 Scopus citations

Abstract

Food allergy is a rapidly growing public health concern because of its increasing prevalence and life-threatening potential. Animal models of food allergy have emerged as a tool for identifying mechanisms involved in the development of sensitization to normally harmless food allergens, as well as delineating the critical immune components of the effector phase of allergic reactions to food. However, the role animal models might play in understanding human diseases remains contentious. This review summarizes how animal models have provided insights into the etiology of human food allergy, experimental corroboration for epidemiologic findings that might facilitate prevention strategies, and validation for the utility of new therapies for food allergy. Improved understanding of food allergy from the study of animal models together with human studies is likely to contribute to the development of novel strategies to prevent and treat food allergy.

Original languageEnglish (US)
Pages (from-to)309-317
Number of pages9
JournalJournal of Allergy and Clinical Immunology
Volume133
Issue number2
DOIs
StatePublished - Feb 2014

Keywords

  • Food allergy
  • anaphylaxis
  • microbiota
  • murine model
  • regulatory T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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